Cadmium (Cd) is associated with male infertility and poor semen quality in humans. Increasing evidence demonstrates that Cd induces testicular germ cell apoptosis in rodent animals. However, the molecular mechanisms of Cd-induced testicular germ cell apoptosis remain poorly understood. In the present study, we investigated the role of endoplasmic reticulum (ER) stress on Cd-evoked germ cell apo...

The last 100 years have seen a concerning decline in male reproductive health associated with decreased sperm production, sperm function and male fertility. Concomitantly, the incidence of defects in reproductive development, such as undescended testes, hypospadias and testicular cancer has increased. Indeed testicular cancer is now recognised as the most common malignancy in young men. Such ca...

INTRODUCTION Testicular tumors are a heterogeneous group of neoplasms exhibiting diverse histopathology and can be classified as seminomatous and non-seminomatous germ cell tumor types. Mixed germ cell tumors contain more than one germ cell component and various combinations have been reported. Here, we present a rare case of a mixed germ cell tumor composed of seminoma, choriocarcinoma and ter...

We report a case of 33-year-old man who initially presented with upper gastrointestinal bleeding caused by metastatic testicular cancer. Physical examination was significant for a palpable abdominal mass. Emergency gastroduodenoscopy yielded an ulcerated infiltrating mass in the third portion of the duodenum. Computerized tomography of the abdomen demonstrated a retroperitoneal mass. Histologic...

Testicular cancer accounts for nearly 1% of all malignant disease in male patients. The annual incidence of testicular cancer in Japan ranges from approximately 0.7 to 1.8/100,000 patients. A total of 90%e95% of testicular cancers are categorized as germ cell tumors, including seminoma and non-seminoma. Other non-germ cell tumors account for <10%. Extramedullary plasmacytoma (EMP) is reported t...

abstract diabetes mellitus (dm) is one of the greatest public health threats in modern societies. although during a few years it was suggested that dm had no significant effect in male reproductive function, this view has been challenged in recent years. from a clinical perspective, the evaluation of semen parameters, as well as spermatozoa deoxyribonucleic acid (dna) integrity, are often studi...

Aim: Testicular tumors are one of the most common malignancies in men age group 15-40 years, although they rarely observed. In our study, it was aimed to evaluate their histopathological features by retrospectively examining cases diagnosed as testicular tumor department. Materials and Methods: Age, localization, size, pathological stage, type frozen information 65 Department Medical Pathology ...