OBJECTIVE The performance of association tests based on case-control or case-parents substudy alone can be improved by jointly using genetic data from two substudies. However, genetic data from different sources may not be combinable due to population stratification. We propose a two-stage association test based on using combinability tests in stage 1 and association tests in stage 2. METHODS...

background : the goal of the present study was to develop and validate the persian version of the acceptable noise level (anl) test in normal, persian-speaking children aged 5-8 years. methods : this tool-making and non-experimental research was conducted in two stages. in the first stage the proper story was selected and recorded after evaluation of its content validity. in the second stage th...

OBJECTIVES Tackling the harm associated with acute kidney injury (AKI) is a global priority. In England, a national computerised AKI algorithm is being introduced across the National Health Service (NHS) to drive this change. The study sought to maximise its clinical utility and minimise the potential for burden on clinicians and patients in primary care. DESIGN An appropriateness ratings eva...

Multiple testing is a problem in genome-wide or region-wide association studies. In this report, we consider a study design given by the Genetic Analysis Workshop 15 (GAW15) Problem 3 - nuclear families (parents with their affected children) and unrelated controls. Based on this design, we propose three two-stage approaches to deal with the problem of multiple testing. The tests in the first st...

This paper presents a new Built-In Self-Test for Pipeline ADC’s. The test set is divided in 3 parts: Monotonicity test for basic functionality verification, DC gain of each stage and frequency bandwidth of each stage. The approach is based on the “Divide and conquer” principle. Adaptive schemes are used to get a precise analog timer, ramp generator and compensation for process variations.

objective: the present study aimed to determine the effect of reminiscence on cognitive status and memory of a sample of elderly people who lived in aged day centers in golestan province, iran. methods: this study was a semi-experimental research. the subjects consisted of 45 elderly people who referred to the aged day centers of golestan province. each four groups of 45 aged subjects (4 groups...

MOTIVATION When a large number of hypotheses are investigated the false discovery rate (FDR) is commonly applied in gene expression analysis or gene association studies. Conventional single-stage designs may lack power due to low sample sizes for the individual hypotheses. We propose two-stage designs where the first stage is used to screen the 'promising' hypotheses which are further investiga...

OBJECTIVE To assess the impact of the National Bowel Cancer Screening Program (NBCSP) in South Australia. DESIGN, SETTING AND PARTICIPANTS A cohort comparison of colorectal cancer (CRC) patient data from the NBCSP register and the South Australian Cancer Registry. Patient records of those invited to take part in screening through the NBCSP, those who participated in the program, and those wit...