This article describes the design of a new test rig for measuring the friction force in pneumatic components and seals. The test rig was designed in order to measure both the overall friction force in a pneumatic cylinder or a valve as a whole, and the single contribution to friction force caused by the sliding seals. To this end, special fixtures and devices were designed and manufactured in o...

Accuracy, reliability, and long lifetimes are critical parameters for sensors measuring temperature in gas turbines of clean coal-fired power plants. Greener high efficiency next generation power plants need gas turbines operating at extremely high temperatures of 1500°C, where present thermocouple temperature probe technology fails to operate with reliable and accurate readings over long lifet...

Vitamin A can significantly decrease measles-associated morbidity and mortality. Vitamin A can inhibit the replication of measles virus (MeV) in vitro through an RARα- and type I interferon (IFN)-dependent mechanism. Retinoid-induced gene I (RIG-I) expression is induced by retinoids, activated by MeV RNA and is important for IFN signaling. We hypothesized that RIG-I is central to retinoid-media...

conclusions our results showed that only 17% of the measured points in the oil drilling rig floor were in safe area; 39% were in caution area and 44% were in danger area. in the camp facilities area, 51% of the points were in safe area, 38% were in caution area and 11% in danger area. the main sources of noise exposure in the rig floor area were power generators. materials and methods this was ...

A description is given of a multi-body dynamics rig for testing a novel rotor fluid film bearing system. The design included a composite rotor supported on a stationary central shaft, with loading applied by non-contacting electromagnets. The shaft included hydrostatic bearing pockets and continuously adjustable hydrodynamic bearing segments. A technique is described for deriving displacement c...

Protein ubiquitination plays an essential role in the regulation of retinoic acid-inducible gene I (RIG-I) activation and the antiviral immune response. However, the function of the opposite process of deubiquitination in RIG-I activation remains elusive. In this study, we have identified the deubiquitinating enzyme ubiquitin-specific protease 4 (USP4) as a new regulator for RIG-I activation th...

The caspase recruitment domain (CARD) of intracellular adaptors and sensors plays a critical role in the assembly of signaling complexes involved in innate host defense against pathogens and in the regulation of inflammatory responses. The cytosolic receptor retinoic acid-inducible gene-I (RIG-I) recognizes viral RNA in a 5'-triphosphate-dependent manner and initiates an antiviral signaling cas...

Exogenous nucleic acids induce an innate immune response in mammalian host cells through activation of the retinoic acid-inducible gene I (RIG-I). We evaluated RIG-I protein for RNA binding and ATPase stimulation with RNA ligands to investigate the correlation with the extent of immune response through RIG-I activation in cells. RIG-I protein favored blunt-ended, double-stranded RNA (dsRNA) lig...

Economic comparison of single-rig and twin-rig trawl for nephrops Economic comparison of single-rig and twin-rig trawl for nephrops

RIG-I senses intracellular virus-specific nucleic acid structures and initiates an antiviral response that induces interferon (IFN) production, which, in turn, activates the transcription of RIG-I to increase RIG-I protein levels. Upon intracellular poly(I:C) stimulation, however, the levels of RIG-I protein did not correlate with the expression patterns of RIG-I transcripts. When the ISG15 con...