Preterm labor is one of the major causes of neonatal mortality and morbidity. Despite significant improvement in care for premature neonates, the most suitable and inexpensive treatment is prevention of preterm labor by inhibiting uterine contractions. The aim of this research is to obtain scientific evidence for the relaxant effect of ketotifen on the rat uterus and to provide the preclinica...

Patients 1970 patients who were > 12 years of age and had mild asthma. 698 corticosteroid free patients (group A) (mean age 31 y, 60% women) had not used an inhaled corticosteroid for > 3 months and had an FEV1 > 80% of predicted normal after inhaling terbutaline, 1 mg. 1272 corticosteroid treated patients (group B) (mean age 37 y, 57% women) were receiving < 400 ìg/day of inhaled budesonide or...

Changes in functional residual capacity and peak flow rate were measured to assess bronchodilator response to terbutaline inhaled via a nebuhaler. In 10 children with asthma, aged 5-7 years, five breaths sufficient to operate the nebuhaler valve resulted in clinically important improvement in both the functional residual capacity and the peak flow rate. In 18 of 22 children, aged 2-5 years, who...

Therefore, any differences in lung deposition need to be supported by clinical data to determine whether they are clinically relevant. Indeed, there are data which show no difference, in terms of improvements in lung function, between the MDI and Turbuhaler in multiple-dose studies with ipatropium bromide [3], terbutaline [4, 5] and budesonide [6] as well as single-dose and cumulative dose stud...

The severity, duration, and reversibility of pentamidine induced bronchial narrowing was studied with and without pretreatment with nebulised terbutaline 10 mg in an open study of 40 patients seropositive for the human immunodeficiency virus (HIV). All subjects received pentamidine 300 mg in 5 ml water via an Acorn System 22 jet nebuliser. The forced expiratory volume in one second (FEV1) fell ...

The research aimed to explore the clinical effect of atomized budesonide and terbutaline inhalation for acute pediatric asthma. Ninety children with mild or moderate asthma treated in our hospital from January 2019 December were selected as study subjects divided into observation group control according using random number table, 45 patients each group. On attack asthma, both groups received tr...

Traylor ZP, Yu EN, Davis IC. Respiratory syncytial virus induces airway insensitivity to -agonists in BALB/c mice. Am J Physiol Lung Cell Mol Physiol 298: L437–L445, 2010. First published December 4, 2009; doi:10.1152/ajplung.00363.2009.— -Adrenergic agonists ( agonists) are commonly used to treat respiratory syncytial virus (RSV) bronchiolitis but are generally ineffective for unknown reasons....

One hundred and eleven children with acute asthma were studied to compare delivery of terbutaline by either a metered dose inhaler (MDI) with a valved holding chamber or a nebuliser driven by air. Eligible patients were randomised; the MDI group received three puffs (0.75 mg) of terbutaline and the nebuliser group received 2 ml (5.0 mg) terbutaline solution diluted with 2 ml 0.9% saline for inh...

OBJECTIVE To determine the utility of inhaled hypertonic saline solution to treat ambulatory infants with viral bronchiolitis. DESIGN Randomized, double-blind, controlled trial. Sixty-five ambulatory infants (mean +/- SD age, 12.5 +/- 6 months) with viral bronchiolitis received either of the following: inhalation of 0.5 mL (5 mg) terbutaline added to 2 mL of 0.9% saline solution as a wet nebu...

Spontaneous contractile force of muscle strips isolated from male rabbit urinary bladder dome (detrusor) and base (trigonal muscle) was significantly inhibited by isoproterenol (10(-7)-10(-5) M), a non-specific beta-adrenoceptor agonist or by terbutaline (10(-8)-10(-5) M), a selective beta 2-adrenoceptor agonist. The EC50 values for isoproterenol and terbutaline in detrusor were the same as tho...