BACKGROUND: Brazil ranks 14 th worldwide in the number of TB cases and 19 terms TB-HIV co-infected cases. This study aims at identifying clinical demographic factors associated with unsuccessful treatment outcomes (loss to follow-up, failure death) HIV-positive patients multidrug-resistant (MDR-TB) Rio de Janeiro State, Brazil. METHODS: was a retrospective cohort MDR-TB notified from 2000 2016 ...

background: a number of former studies have shown that tuberculosis (tb) is higher in diabetes mellitus (dm) patients than non-diabetics. both dm and tb are major public health problems in iran, and because of the lack of investigation in this field in the region, we conducted this study to evaluate the prevalence of dm in admitted pulmonary tuberculosis patients. methods: the medical files of ...

background certain social determinants may influence host susceptibility to tuberculosis (tb) infections, and increase the risk of developing the disease. objectives the present study aimed to evaluate the effects of several host and environmental factors on the risk of tb in northern iranian households. patients and methods this case-control study was conducted for one year between 2010 and 20...

patients and methods in this cross-sectional study, peripheral mononuclear cells (pbmcs) were isolated from peripheral blood of 29 patients with newly diagnosed pulmonary tb and 19 patients with positive tuberculin skin test. the pbmcs were activated with ppd for 72 hours. activated cells were harvested, rna was extracted and cdna was synthesized. a real-time taqman method was designed and opti...

background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

Background: India is a high burden country for Tuberculosis (TB). As per the World Health Organization (WHO) statistics, 24000 cases of Multi Drug Resistant (MDR) TB were diagnosed in India in 2014. MDR-TB patients consist of a heterogeneous cohort and management has its challenges. Aims and objectives: We studied the prevalence of PreExtensively Drug Resistant TB (Pre XDR-TB) and Extensively D...

Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease caused by Mycobacterium which resistant to at least isoniazid and rifampicin. This a worldwide threat complicates the control of (TB). Long treatment duration, combination several drugs, adverse effects these drugs are factors that play role in poor outcomes MDR-TB patients. There have been many studies with repurposed improve o...

ObjectivesIsoniazid-monoresistant tuberculosis (HR-TB) is the most prevalent form of drug-resistant TB worldwide and in France associated with poorer treatment outcomes compared drug-susceptible (DS-TB). The objective this study was to determine characteristics HR-TB patients compare safety for DS-TB.MethodsWe performed a case-control multicenter identify risk factors between DS-TB patients.Res...

BACKGROUND Simple biomarkers are required to identify TB in both HIV(-)TB(+) and HIV(+)TB(+) patients. Earlier studies have identified the M. tuberculosis Malate Synthase (MS) and MPT51 as immunodominant antigens in TB patients. One goal of these investigations was to evaluate the sensitivity and specificity of anti-MS and -MPT51 antibodies as biomarkers for TB in HIV(-)TB(+) and HIV(+)TB(+) pa...

it is estimated that one third of the world's population is latently infected with tuberculosis (tb). the hiv epidemic fuels the tb epidemic by increasing the risk of reactivation of latent tb infection and by facilitating a more rapid progression of tb disease. although the incidence of tb is constant or decreasing in many regions of the world, rates remain high in developing countries as a co...