Tinidazole is a broad spectrum antiprotozoal agent having bitter taste. The present study concerns to mask the bitter taste of tinidazole as an orally disintegrating tablet (ODT) using Indion 294 and Indion 204 (ion exchange resin) as a taste masking agent. In first method, 1:1, 1:2 and1:3 ratios of drug and resin were stirred for six hour. Percent drug losses were found to be on higher side in...

The orally disintegrating tablet (ODT) has shown vast potential as an alternative oral dosage form to conventional tablets wherein they can disintegrate rapidly (?30 s) upon contact with saliva fluid and should have acceptable mouthfeel long their weight doesn’t exceed 500 mg. However, owing the bitterness of several active ingredients, there is a need find suitable ODTs that maintains features...

Primaquine is an important antimalarial drug for malaria transmission blocking and radical cure, but it not currently available in child-friendly formulations appropriate doses. Adult-strength tablets are often crushed dissolved water to obtain the required dose, which exposes drug’s bitter taste. As part of developing paediatric primaquine (DPP) project, this study adopted a responsive sensory...

BACKGROUND Chlorpheniramine maleate (CM) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. OBJECTIVES The purpose of this research was to mask the bitter taste of CM by formulating microspheres of the taste-masked drug. MAT...

matococcus daniellii Benth.i) The moleculaT mass of the protein is 22 kDa and the higher order structure of the protein is maintained by eight disulfide bridges.2・3) Thaumatin is the sweetest substance for man and is, on a molar basis, 100,OOO times sweeter than sucrose.i) Today, thaumatin is used commercially for its intense sweetness, taste masking, fiavor enhancement, and synergistic propert...