It has been reported! by Simon 1) that several synthetic analogs of the morphine series are strong inhibitors of bacterial growth. Simon attributes this effect to selective inhibition of ribosomal RNA synthesis (2, 3). We have studied the effects of the most potent of these drugs, levallorphan tartrate, on macromolecular synthesis in Escherichia coli. This d!rug was selected for study because i...

A rare case of ergotamine-induced solitary rectal ulcer is described in a 41 year old woman who used high doses of ergotamine tartrate-containing suppositories for severe migraine headaches. Complete recovery of the ulcer was noticed after cessation of treatment with the suppositories. The relevant literature is discussed.

In a previous publication3 it was shown that spinal transection is followed by a pronounced reduction of tissue permeability.' Since it is known that spinal reflex centers for the liberation of epinephrine are located in the thoracic segment of the splnal cord,4 and since Favilli reported a reduction in skin permeability after.epinephrine injections, the question arose as to whether the liberat...

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Unlike epidemics in past centuries, patients suffering from peripheral vascular ischemia related to ergotism now rarely lose a limb because of vasodilator therapies. We report a patient with ischemia from ergotamine tartrate who failed to recover with medical therapy, resulting in limb amputation.

The structures of two compounds of L-tartaric acid with quinoline, viz. the proton-transfer compound quinolinium hydrogen (2R,3R)-tartrate monohydrate, C9H8N+.C4H5O6-.H2O, (I), and the anhydrous non-proton-transfer adduct with quinaldic acid, bis(quinolinium-2-carboxylate) (2R,3R)-tartaric acid, 2C10H7NO2.C4H6O6, (II), have been determined at 130 K. Compound (I) has a three-dimensional honeycom...

Classical migraine, including incapacitating visual field defects, repeatedly developed in five young men immediately after blows to the head while playing football and in no other circumstances. A similar condition occurred in a professional boxer and an isolated attack in a boy footballer. Prophylactic treatment with ergotamine tartrate may not be wholly successful and it may be necessary to ...

A dioxane homo-sugar analog, (2S,5S)-and (2R,5S)-5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-iodomethyl-1,4-dioxane was prepared from (2R,3R)-dimethyl tartrate, and further elaborated into the corresponding homo-N-nucleoside analogs by its reactions with uracil and adenine, respectively.

Three laboratories in the U.S. and two in the Netherlands determined molar absorptivities (epsilon) of Standard Reference Material (SRM) 916a Bilirubin from the National Institute of Standards and Technology. In caffeine reagent the average epsilon values were 50,060 and 48, 980 L.mol-1.cm-1 at 432 and 457 nm, respectively. The epsilon value of the blue azopigment, obtained with the Reference M...

DOMINO, E. F. AND M. P. LUTZ. Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement. PHARMAC, BIOCHEM. BEHAV. 1(4) 445-448, 1973.-The effects of daily nicotine tartrate given IP in a dose of 0.25 mg/kg twice a day for 15 days was studied on bar pressing behavior for water reinforcement in the rat. A modified FR t 5 schedule was used. Nicotine injections...