Aim: Hyoscyamus niger (Solanaceae) has been used for treatment of mental disorders, epileptic mania, chronic dementia with insomnia. However, it is not yet studied in condition like depression. The present study was planned with an objective to evaluate its antidepressant like property in animal models of depression and to find out the possible mechanism underlying this action in mouse model of...

OBJECTIVE To evaluate antidepressant like effect of tramadol in mice. MATERIALS AND METHODS Tramadol was administered at three different doses (10,20 and 40 mg/kg, i.p) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug treated mice were recorded in tail suspension test (TST).The antidepressant effect of tramadol was compared to that of fluoxet...

In this work we evaluated antidepressant-like effect of E. uniflora leaves EO employing the tail suspension test. The involvement of serotonergic and adrenergic systems was appraised. EO was administered by oral route (p.o.) in mice and the doses of 10 and 50mg/kg exhibited antidepressant-like action in the TST. The effect of EO (10mg/kg) was prevented by the pretreatment of mice with ketanseri...

In the present study, antidepressant-like effects of piperine (PIP) and its derivative, antiepilepsirine (AES), were investigated in two depressive models: forced swimming test (FST) and tail suspension test (TST). To further explore the mechanisms underlying their antidepressant-like activities, the brain monoamine levels and monoamine oxidase A and B (MAO-A and MAO-B) activities were also det...

BACKGROUND Animal models of human behavioral endophenotypes, such as the Tail Suspension Test (TST) and the Open Field assay (OF), have proven to be essential tools in revealing the genetics and mechanisms of psychiatric diseases. As in the human disorders they model, the measurements generated in these behavioral assays are significantly impacted by the genetic background of the animals tested...

Background & Aim: Depression is a heterogeneous mood disorder affecting both people in developing and developed countries. The drugs used in its management are associated with adverse effects and delayed response which compromise their therapeutic benefits. This makes it worthwhile to look for antidepressants plants with proven advantage and favourable benefit-...

Background & Aim: Depression is a heterogeneous mood disorder affecting both people in developing and developed countries. The drugs used in its management are associated with adverse effects and delayed response which compromise their therapeutic benefits. This makes it worthwhile to look for antidepressants plants with proven advantage and favourable benefit-...

Agmatine is an endogenous neuromodulator that has been shown to have antidepressant-like properties. We have previously demonstrated that it can induce a rapid increase in BDNF levels after acute administration, suggesting that agmatine may be a fast-acting antidepressant. To investigate this hypothesis, the present study evaluated the effects of a single administration of agmatine in mice subj...

Mouse strain differences in immobility and in sensitivity to antidepressants have been observed in the forced swimming test (FST) and the tail suspension test (TST). However, the neurotransmitter systems and neural substrates that contribute to these differences remain unknown. To investigate the role of the hippocampal serotonin transporter (5-HTT), we measured baseline immobility and the immo...

BACKGROUND Psychological stressors may cause affective disorders, such as depression and anxiety, by altering expressions of corticotropin releasing factor (CRF), serotonin (5-HT), and tyrosine hydroxylase (TH) in the brain. This study investigated the effects of essential oil from Asarum heterotropoides (EOAH) on depression-like behaviors and brain expressions of CRF, 5-HT, and TH in mice chal...