HYPOTHESIS The incidence of sentinel node (SN) metastases from invasive breast cancer might be affected by the technique used to obtain biopsy specimens from the primary tumor before sentinel lymph node dissection. DESIGN Prospective database study. SETTING The John Wayne Cancer Institute. PATIENTS AND METHODS We identified 663 patients with biopsy-proven invasive breast cancer who underw...

Since therapeutic peptides and oligonucleotides are gathering interests as active pharmaceutical ingredients (APIs), nanoparticulate drug delivery systems are becoming of great importance. Thereby, the possibility to design drug delivery systems according to the therapeutic needs of APIs enhances clinical implementation. Over the last years, the focus of our group was laid on protamine-oligonuc...

At present, drug dosage is based on standardised approaches that disregard pharmakokinetic differences between patients and lead to non-optimal efficacy and unnecessary side effects. In this work, we demonstrate the potential of pH-mediated fluorescence spectroscopy for therapeutic drug monitoring in complex media. We apply this principle to the simultaneous quantification of the chemotherapeut...

The new class of homo- and heteroleptic n-butyl-N,N'-disubstituted amidinato group 14 metal(II) complexes were prepared by salt elimination from starting lithium amidinates and metal(II) chlorides both in stoichiometric ratio 2:1 and 1:1, respectively. The target amidinates contain less bulky isopropyl or cyclohexyl as well as a sterically demanding aromatic substituent. Desired 1:1 Pb(II) comp...

Although in many cases Pb isotopic analysis can be relied on for provenance determination of ancient bronzes, sometimes the use of "non-traditional" isotopic systems, such as those of Cu and Sn, is required. The work reported on in this paper aimed at revising the methodology for Cu and Sn isotope ratio measurements in archaeological bronzes via optimization of the analytical procedures in term...

hinotecan (7.ethyl-1O.[4-(1.piperidino)-1-piperidlnolcarbonyloxy. camptothecin (CPT-11) Is hydrolyzed by the enzyme carboxyl esterase to 7-ethyl-lO-hydroxycamptothecin (SN-38), which further undergoes glucu ronic acid conjugation to form the corresponding SN.38 glucuronide (SN-38G). SN-38 is believed to be the cause oftreatment-related diarrhea, a dose-limiting tOxiCityof CPT-1l observed in pha...