In the 15-mer catalytic core of 10-23 DNAzyme, each residue contributes to the catalytic conformation differently. Here, the critically conserved T4 and the least conserved T8 were modified on their 5-position with hydroxyl, imidazolyl, and amino groups with a hydrogen-bonding ability. These external functional groups induced new interactions within the catalytic core, resulting in both negativ...

T lymphocyte lines have been established, with the addition of interleukin-2 (IL-2), from the synovial fluid (SF) of patients with arthritis. Characterisation of seven of these SF-derived T cell lines showed them to be T3+, T11+, and to contain a significant proportion of T8+ cells (mean 41%). The proportion of T4+ cells varied among the lines, with a mean T4+/T8+ ratio of 0.6. A significant au...

The influence of T lymphocyte (T cell) subsets on the proliferation of the blood neutrophilic. macrophagic. and eosinophilic cluster and colony (aggregate) forming cells (CFC) was evaluated. The T cells and the CFC-enriched Bnull cells (mononuclear cells depleted of monocytes and T cells) and null cells (Bnull cells depleted of B lymphocytes) were separated from the blood of normal individuals....

The field trial was conducted in Central Research Farm (CRF) at SHUATS, Prayagraj, during Kharif-2021-22. experiment laid out RBD (Randomized Block Design) and replicated thrice with seven treatments. Viz., T1 Indoxacarb 14.5%EC, T2 Flubendiamide 39.5%SC, T3 Emamectin benzoate 5%SG, T4 Bacillus thuringiensis 5% WP, T5 Spinosad 45% SC, T6 Neem oil 4%, T7 Chlorantraniliprole 18.5%SC, (T8) untreat...

Al-0.9Si-0.6Mg (wt%) alloy conductive wires were designed and produced by continuous rheo-extrusion process. The effects of different heat treatment on microstructure, mechanical and conductive properties of the wires were studied. Results show that, after T6 heat treatment, conductive property of the alloy increased while elongation decreased with the higher aging temperature and longer aging ...

We investigated the relationship of the presence of antibodies to HTLV-III and immunologic abnormalities in patients with hemophilia. Serum antibodies to HTLV-III were analyzed by ELISA assay, immunoprecipitation of labeled cell extracts, and immunoprecipitation of purified HTLV-III p24. Thirty-four (61%) of the total group (n = 56) had antibody to HTLV-III; 34 (76%) of 45 patients given commer...

The research was conducted to study the effect of heat stress on blood parameters in indigenous sheep. Nine sheep were divided into three groups which were almost similar in age, sex and weight. Three groups were divided as zero hour (T0), four hours (T4) and eight hours (T8) heat exposure to direct sunlight. During experimental period temperature–humidity index (THI) value was calculated as 27...

The present study evaluates different cellular and soluble components in the bronchoalveolar lavage (BAL) from patients with interstitial lung disease. We observed an increased T4/T8 lymphocyte ratio in BAL but not in blood from 24 patients with active pulmonary sarcoidosis compared to sixteen normal individuals and to eleven patients with inactive pulmonary sarcoidosis. Seven patients with hyp...

Conditioned medium derived from peripheral mononuclear low-density cells stimulated with phytohemagglutinin (PHA) supports the growth of noncommitted hematopoietic progenitors from marrow and peripheral blood cells. These immature progenitors (CFU-GEMM) can be identified in culture as multilineage hematopoietic colonies containing erythroblasts, eosinophilic, basophilic and neutrophilic granulo...