BACKGROUND The efficacy of cardiac iron chelation in transfusion-dependent patients has been demonstrated in one-year prospective trials. Since normalization of cardiac T2* takes several years, the efficacy and safety of deferasirox was assessed for two years in patients with β-thalassemia major in the cardiac sub-study of the EPIC trial. DESIGN AND METHODS Eligible patients with myocardial T...

Central thyroid hormone signaling is important in brain function/dysfunction, including affective disorders and depression. In contrast to 3,3',5-triiodo-L-thyronine (T3), the role of 3,5-diiodo-L-thyronine (T2), which until recently was considered an inactive metabolite of T3, has not been studied in these pathologies. However, both T3 and T2 stimulate mitochondrial respiration, a factor count...

The effect of high dietary intakes of vitamin E on antibody production was investigated in chicks and turkeys. Chicks were fed four diets with 0, 10, 30, and 150 mg/kg added vitamin E and turkeys were fed three diets with 0, 50, and 150 mg/kg added vitamin E. Antibodies produced in response to naturally occurring Escherichia coli and to Newcastle disease virus and turkey pox vaccines were deter...

7-Nitroindazole (7NI, a nitric oxide synthase [NOS] inhibitor) administered intraperitoneally (ip), 30 min before the test, at doses ranging between 50-200 mg/kg, raised the threshold for electroconvulsions in mice. Linear regression analysis revealed that the doses increasing the threshold by 50% (TID50) and 100% (TID100) over the control value for 7NI were 115.2 and 173.4 mg/kg, respectively....

The prophyalactic contributions of spirulina and thankuni on rats experimentally induced with arsenic toxicity were tested and the comparative efficacies of both spirulina and thankuni were determined. Sixty apparently healthy rats were received, divided into 5 groups (T0 for control, T1 for arsenic treated group, T2 for arsenic plus spirulina treated group, T3 for arsenic plus thankuni treated...

Experiment was conducted on 120 broiler chicks for six weeks and their weight gain was taken for consecutive six weeks to observe the effect of different levels of dietary selenium over growth and nutrient utilization of birds. There were three diets prepared with 0.125, 0.15 and 0.175 mg Se/Kg feed for group T1, T2 and T3 respectively. The FCR and st performance index at 1 week for T1 were 1.3...

A field experiment was conducted to study the effect of iron fertilization on growth, yield and quality groundnut (Arachis hypogaea L.) during kharif, 2016 (June September at instructional farm, Swami Keshwanand Rajasthan Agricultural University, Bikaner, Rajasthan, India. Twelve treatments viz. T1: control (water spray); T2: FeSO4 basal @ 25 kg ha-1; T3: Foliar spray citric acid 0.1% 45 75 day...

Ambruticin (W7783) was evaluated in vivo in mice subacutely or nonlethally infected with Histoplasma capsulatum. Results were compared with those obtained with amphotericin B, the drug of choice in human histoplasmosis. In one experiment, ambruticin was shown to be capable of curing infected animals as evidenced by totally negative liver and spleen cultures obtained when mice were sacrificed af...

The present study was carried out to evaluate the effect of supplementation exogenous fibrolytic enzymes (EFE) on voluntary feed intake, availability different nutrients and growth performance in weaned crossbred calves. Fifteen healthy female Jersey calves (weight 79.73±3.46 kg; age 234.5±11.33 days) were divided equally into three groups viz., Control (T0), Treatment-1 (T1) Treatment-2 (T2). ...

Field experiment was carried out on silt clay loam soils at Regional Agricultural Research station, Chintapalle, Visakhapatnam, Andhra Pradesh during 2018-2020 to study the yield of response rainfed groundnut with different levels Nano particulate zinc oxide application along NPK Fertilizers. The consisting eight treatments, three replications RDF design. Results nano pod showed that (24.36 Q/h...