T-lymphocyte populations in 12 apparently healthy heterosexual adult patients with hemophilia have been examined to ascertain if these patients have abnormalities in their lymphocyte subpopulations similar to those in homosexual men, Haitian refugees, and narcotic addicts. A striking reduction in the helper to suppressor cell ratio ([0.86 +/- 0.14]:1) was found in 9 of the 12 patients. These ab...

It has recently been shown that hapten-modified cultured Langerhans cells are able to activate small resting syngeneic L3T4+ T helper cells from nonsensitized animals. Repeated stimulation of these T cells with hapten-modified cultured Langerhans cells leads to the establishment of L3T4+ hapten-specific interleukin-4-producing T-cell lines. Here we report on further characteristics of primary h...

BACKGROUND Iron-deficiency anaemia (IDA) is a major worldwide public health problem. Children and women of reproductive age are especially vulnerable to IDA, and it has been reported that these patients are more prone to infection. This study was done to evaluate alteration of lymphocyte subgroups in IDA. METHODS In this prospective study, we investigated lymphocyte subsets in pre-menopausal ...

Immunocytological properties of the splenic T cell (Tv) which develop into virus plaque-forming cells in response to the antigenic challenge in vitro were investigated in relation to the properties of helper T cells and suppressor T cells in antibody response. Tv was observed in spleen around 1 wk after the intravenous injection of mice with 10(7) sheep erythrocytes. This contrasted with the fi...