BACKGROUND trans-Resveratrol (t-Res) is a natural phenolic compound with various biological activities such as antioxidant, anticancer, cancer chemopreventive, cardioprotective, and neuroprotective. OBJECTIVES There is no comprehensive study about the stability of t-Res in human plasma. With respect to extensive use of t-Res in clinical trials and pharmacokinetic studies, in this study, we ai...

Sequence Generator Projection Constraint Conjunction 1 scheme(612,34,18,34,1) id alldifferent*18 2 scheme(612,34,18,2,2) id alldifferent*153 3 scheme(612,34,18,1,18) id alldifferent*34 4 scheme(612,34,18,1,18) absolute value symmetric alldifferent([1..18])*34 5 scheme(612,34,18,17,1) absolute value alldifferent*36 6 repart(612,34,18,34,9) id sum ctr(0)*306 7 repart(612,34,18,34,9) id twin*1 8 r...

Harraz OF, Brett SE, Welsh DG. Nitric oxide suppresses vascular voltage-gated T-type Ca channels through cGMP/PKG signaling. Am J Physiol Heart Circ Physiol 306: H279–H285, 2014. First published November 15, 2013; doi:10.1152/ajpheart.00743.2013.— Recent reports have noted that T-type Ca channels (CaV3.x) are expressed in vascular smooth muscle and are potential targets of regulation. In this s...

Since the discovery of endothelin (ET)-1 in 1988, the main components of the signalling pathway have become established, comprising three structurally similar endogenous 21-amino acid peptides, ET-1, ET-2 and ET-3, that activate two GPCRs, ETA and ETB . Our aim in this review is to highlight the recent progress in ET research. The ET-like domain peptide, corresponding to prepro-ET-193-166 , has...

Bone marrow aspirates from 306 patients with multiple myeloma were analyzed by flow cytometric immunophenotyping. The plasma cells (PCs) were identified by their characteristic light scatter distribution and reactivity patterns to CD138, CD38, and CD45. Monoclonality was confirmed by immunoglobulin light chain analysis. The immunophenotypic profile of the PCs was determined with a panel of anti...

levels were evaluated in all patients. All assays were carried out in duplicate. Skin prick tests on the forearm were performed in all patients using standardized latex extract containing high ammonia natural rubber latex, and a full set of 35 common. In addition, venom SPT was performed on one patient based on the subject’s clinical history. Positive tests were counted as wheals of 3 mm in dia...

Activation of cGMP phosphodiesterase (PDE) by the rod G-protein transducin is a key event in visual signal transduction in vertebrate photoreceptor cells. Interaction between the GTP-bound form of the alpha-subunit of transducin (alpha t*) and the PDE inhibitory gamma-subunit (P gamma) is a major component of PDE activation. The central polycationic region of P gamma, P gamma-24-45, has been im...