BACKGROUND There is a renewed interest in thalidomide therapy after its surprising effectiveness in treating erythema nodosum leprosum was first published. Thalidomide has subsequently been reported to be effective in treating a number of dermatoses, including cutaneous lupus erythematosus. We examined the efficacy and adverse effects of low-dose, long-term thalidomide monotherapy in 7 patients...

Rowells syndrome is a rare disease, combining Lupus Erythematosus (LE) and Erythema Multiforme (EM) like lesions with characteristic immunological pattern, including speckled pattern of Antinuclear Antibodies (ANA), positive anti Ro SSA or La SSB antibodies Rheumatoid Factor (RF)

the most seasoned and savvy clinician views lupus warily, considering it one of the most bewildering diseases in all of medicine. Th is situation should not be a surprise since the manifestations of lupus are dizzying in their variety and exasperating in their subtlety. Furthermore , although lupus has been at the heart of immuno-logy research for decades, investigators have yet to fi gure out ...

OBJECTIVES To evaluate treatment with the peptide-based agent, Lupuzor, in a double-blind, randomised, placebo-controlled study of patients with systemic lupus erythematosus. METHODS Patients who met ≥4 of the American College of Rheumatology criteria, had a score of ≥6 on the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and did not have an A score on the British Isles...

A 43-year-old woman presented with erythematous papules and plaques on the forehead evolving in the previous 3 months (Fig. 1). Diascopy, by showing a yellowish nodule-like aspect (Fig. 2), raised the hypothesis of cutaneous sarcoidosis, which was confirmed by histopathological examination. Sarcoidosis is a multisystemic granulomatous disease, a histologically evident characteristic shared by i...

Annular erythema (AE) associated with anti-Ro (SSA) and/or La (SSB) autoantibody in patients with Sjögren syndrome (SS) or with SS/systemic lupus erythematosus overlap syndrome (SS/SLE), has recently been described in Orientals, and it may be a counterpart of annular skin lesion of the subacute cutaneous LE seen mostly in Caucasians. The author examined five Korean AE patients in respect to din...

The lupus anticoagulant was found in the plasma of 31 of 60 patients with systemic lupus erythematosus and other connective tissue disorders (mixed connective tissue disease, systemic vasculitis, polyarteritis nodosa, primary sicca syndrome, discoid lupus, Behcet's syndrome, and systemic sclerosis). Strong associations were found with biological false positive seroreaction for syphilis and thro...

Discoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus erythematosus. It tends to heal with scarring, hair loss, and pigmentary changes if treatment is not initiated in the early phase of the disease. Classic DLE lesions are initially red-purple macules, papules, or small plaques that rapidly acquire a hyperkeratotic appearance. Only a minority of patients with DLE...

Angioedema secondary to C1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. A genetic defect of C1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported.In lupus patients, angioedema may be the result of an ac...