Objective: Tramadol is a synthetic analgesic with two mechanisms. The opioid and non-opioid mechanisms are responsible for tramadol side effects. Non-opioid side effects of tramadol are due to the reuptake inhibitions of serotonin and norepinephrine. Some of the side effects include anaphylactoid reactions, CNS depression, hypoglycemia, hypotension, respiratory depression, seizures, and seroton...

Narcotics are substances or drugs that natural, synthetic, semi-synthetic which causes a loss of consciousness, hallucinations, and excitability. Excessive use these can cause addiction, decreased changes in brain cells, quality life, even lead to death. During the COVID-19 pandemic, challenges handling preventing were higher it impact difficult economic conditions allow people drugs. The socia...

The United States is experiencing an epidemic of drug overdose (poisoning) deaths. Since 2000, the rate of deaths from drug overdoses has increased 137%, including a 200% increase in the rate of overdose deaths involving opioids (opioid pain relievers and heroin). CDC analyzed recent multiple cause-of-death mortality data to examine current trends and characteristics of drug overdose deaths, in...

the synthesis of 1,5-dihydroxy-9,10-anthraquinone (17); (1,5-dha) was accomplished during, attempts towards the synthesis one of its derivatives called anthralin (1,8-dihydroxy-9-anthrone) which is known as an antipsoriasis drug since 1916 [1]. this work is a new reigiospecilic preparation of 1,5-dha based on friedel-crafts reaction starting from 1,4-dimethoxybenzene. this synthetic route, in a...