OBIECTIVE AND IMPORTANCE: We pr€sent a case report of a patient wilh a left frontal brain abccess. Cultures obtained fiom the abecess at lhe time of suqgery were idenlified as dental flora knovm to establish a synergistic relationslrip in polymicrobial infections. Ihis type of synergistic relalionship nukes the clearance of an infeclion more difficult for an intact immune sydem. A serum immunog...

Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer's disease patients. An alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both histaminergic and cholinergic pathways, to create a synergistic effect. To that aim, 14 month old C57/Bl6 mice were administered per oesophagy during nine consecutive ...

PURPOSE Gemcitabine is an inhibitor of ribonucleotide reductase (RR) and DNA synthesis and is an effective agent in the treatment of pancreas cancer. The present study investigates whether the multitargeted antifolate pemetrexed would be synergistic with gemcitabine against MIA PaCa-2, PANC-1, and Capan-1 pancreatic cancer cell lines. EXPERIMENTAL DESIGN Cells were treated with gemcitabine an...

For any given taxonomic divergence event, one may find in the literature a wide range of time estimates. Many factors contribute to the variation in molecular date estimates for the same evolutionary event. High on the list is the choice of calibration points for converting genetic distances into evolutionary rates and, subsequently, into dates of divergence. In this study, we investigate one c...

Individuals with Parkinson's disease and the aged have a high prevalence of falls. Since an increase in the number of falls is associated with physical and psychological harm, it is prudent that biomechanical metrics be established that will accurately assess an individual's walking balance. In this investigation, we initially used a simple bipedal walking computer model to theoretically establ...

Plants have evolved efficient defense mechanisms known as priming and synergy, both of which can mobilize defense responses more extensively against successive pathogen invasion or simultaneous stimulation by different signal molecules. However, the mechanisms underlying these phenomena were largely unknown. In the present study, we used cultured rice cells and combination of purified MAMP mole...

The glycans on HIV-1 gp120 play an important role in shielding neutralization-sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study, we investigated the interaction of the lectin griffithsin (GRFT) with HIV-1 gp120 and its effects on exposure of the CD4-binding site (CD4bs). We found that GRFT enhanced the binding of H...

PSC has architected and delivered the TCS-1 machine, a Terascale Computing System for use in unclassified research. PSC has enhanced the effective usability and utilization of this resource by providing custom I/O solutions in four key areas: high-performance communication, highperformance file migration, checkpoint/recovery and an updated hierarchical storage management system. These I/O solut...

Communication between the 5' cap structure and 3' poly(A) tail of eukaryotic mRNA results in the synergistic enhancement of translation. The cap and poly(A) tail binding proteins, eIF4E and Pab1p, mediate this effect in the yeast S. cerevisiae through their interactions with different parts of the translation factor eIF4G. Here, we demonstrate the reconstitution of an eIF4E/eIF4G/Pab1p complex ...

This paper presents “Magnebots ”, a simple yet novel concept for overhead transportation. The system consists of vehicles with magnetic wheels that move on trackless ferromagnetic walls and ceilings, driven by on -board controllers and commanded by a central computer. Magnebots is designed to be a fundamentally simple technology that can fulfill many generic transportation needs including facto...