Background. High-quality clinical and genetic descriptions are crucial to improve knowledge of orofacial clefts and support specific healthcare polices. The objective of this study is to discuss the potential and perspectives of the Brazilian Database on Orofacial Clefts. Methods. From 2008 to 2010, clinical and familial information on 370 subjects was collected by geneticists in eight differen...

Congenital cleft-Lip and cleft palate has been the subject of many genetic studies, but until recently there has been no consensus as to their modes of inheritance. In fact, claims have been made for just about every genetic mechanism one can think of. Recently, however, evidence has been accumulating that favors a multifactorial basis for these malformations. Cleft lip and palate (CLP) are bir...

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is the most common birth defect. The gene interferon regulatory factor 6 (IRF6) is the most studied candidate-cause of clefts of the lip, palate, or both. Variations of IRF6 are associated with ethnicity. We investigated the presence of 8 tag SNPs of IRF6 in residents of Guangdong province: 126 patients with NSCL/P (29 with cleft lip...

Objective: To identify the incidence of recurrent otitis media in cleft palate patients after palatoplasty and myringotomy \14 ";">with ventilation tube (VT) insertion addition to identifying risk factors with effusion (OME). Material Methods: This retrospective cohort study was conducted from; January 2002 – December 2014. A total 120 non- syndromic were included analyzed for contributing "...

OBJECTIVE To determine retraction and alignment of protruded and rotated premaxillary segment and to measure increase in columellar length by using modified orthopaedic plate with anterior acrylic ring in newborn babies with non syndromic bilateral cleft lip and palate. METHODS Pre surgical infant orthopaedic treatment of ten non syndromic bilateral cleft lip and palate new born babies was do...

Clefts of the lip and/or palate (CL/P) are immediately recognizable disruptions of normal facial structure. Approximately 1 in 700 children born have a cleft lip or a cleft palate or both with a lifetime cost of treatment estimated at $200,000. CLP and CP individuals may experience difficulties in feeding, speaking, hearing and social integration. Recent successes in genome-wide linkage and ass...

To discuss the embryological basis, sequela and management of intraoral synechia, and to report on the incidence of this condition at a facial cleft deformity clinic (FCDC), with specific attention to two rare cases of mucosal bands involving the floor of the mouth and palate. Review of the literature and a retrospective analysis of FCDC and case report of two cases. During the period of 30 yea...

Dental anomalies are common congenital malformations that can occur either as isolated findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth development and the implications of these abnormalities for clinical care. As an introduction, we describe general insights into the genetics of tooth development obtained from mouse and zebrafish models. This is follow...