NEUROTROPHIN EXPRESSION IN SYMPATHETIC NEURONS: INFLUENCES OF EXOGENOUS NGF AND AFFERENT INPUT by Elizabeth Ellen Jones The regulatory mechanisms that promote the survival of adult neurons remain unclear. Targetderived proteins called neurotrophins are known to play a role in the survival of sympathetic neurons, but their exact function is unknown. In the present study, expression of the neurot...

The functional peripheral cardiac sympathetic pathways of the dog were delineated in isovolumetric left ventricle preparations. In unpaced hearts, supramaximal stimuli at 2 cycles/sec to the right stellate ganglion caused the heart rate to increase 2.8 times more than stimuli applied to the left side. In paced hearts, such stimuli evoked rises in left ventricular systolic pressure which were 2....

In a most suggestive paper " On the structure, distribution and function of the nerves which innervate the visceral and vascular systems," Gaskell (I) drew attention to the fact that physiological differences observed in peripheral nerves are bound up with morphological differences, so that groups of nerves of the same function can be grouped under the same morphological laws of structure and d...

A rat model of lumbar root constriction with an additional sympathectomy in some animals was used to assess whether the sympathetic nerves influenced radicular pain. Behavioural tests were undertaken before and after the operation. On the 28th post-operative day, both dorsal root ganglia and the spinal roots of L4 and L5 were removed, frozen and sectioned on a cryostat (8 microm to 10 microm). ...

G-protein-coupled receptor 41 (GPR41) also called free fatty acid receptor 3 (FFAR3) is a Gαi-coupled receptor activated by short-chain fatty acids (SCFAs) mainly produced from dietary complex carbohydrate fibers in the large intestine as products of fermentation by microbiota. FFAR3 is expressed in enteroendocrine cells, but has recently also been shown to be present in sympathetic neurons of ...