PURPOSE The aim of the study was to investigate the feasibility of (18)F-3'-fluoro-3'-deoxy-L-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS). EXPERIMENTAL DESIGN Nineteen patients with 20 STSs of the extremities were scanned, using attenuation corrected whole-body FLT-PET. Standardized uptake values (SUVs) and tumor:nontumor ratios ...

Background: Evaluating the potential role of standardized uptake value (SUV) in patients with locally advanced, non-metastased, high-grade, extremity soft tissue sarcoma. Methods: Thirteen patients scheduled for hyperthermic isolated limb perfusion (ILP), referred for a 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)-scan were eligible. The SUV in the sarcoma lesion was calculat...

Results Of the twenty nine patients, 21 underwent CT-guided FNAB with histological analysis and for 8 “wait and watch strategy”was adopted. Seventeen patients showed malignant SPN and four patients had benignant SPN at CT-guided FNAB. In patients with definite histology the specificity of SPV was 75% compared to 83% of SUV; the sensitivity (88%), the accuracy (85%) and the positive predictive v...

Purpose: The aim of the study was to investigate the feasibility of F-3 -fluoro-3 -deoxy-L-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS). Experimental Design: Nineteen patients with 20 STSs of the extremities were scanned, using attenuation corrected whole-body FLT-PET. Standardized uptake values (SUVs) and tumor:nontumor ratios (TNT...

OBJECTIVE The purpose of this study was to determine whether a repeated antenatal ultrasound examination improves fetal cardiac visualization for the obese and nonobese population. METHODS A computerized ultrasound database (October 1999-June 2003) was used to identify singleton pregnancies undergoing repeated prenatal ultrasound examinations because of initial suboptimal ultrasonographic vis...

The purpose of this study is to assess predictive value of the positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) for recurrence and survival after radiotherapy (RT) for non-small cell lung cancer (NSCLC). One hundred forty-nine patients underwent pretreatment PET (n = 67) or PET/computed tomography (CT) (n = 82) and definitive RT for NSCLC. We evaluated the relationship betw...

Excessive exposure to solar UV (SUV) is related with numerous human skin disorders, such as skin inflammation, photoaging and carcinogenesis. T-LAK cell- originated protein kinase (TOPK), an upstream of p38 mitogen-activated protein kinase (p38) and c-Jun N-terminal kinases (JNKs), plays an important role in SUV -induced skin inflammation, and targeting TOPK has already been a strategy to preve...

UNLABELLED No validated predictive biomarkers for antiangiogenic treatment of metastatic renal cell carcinoma (mRCC) exist. Tumor vascular endothelial growth factor A (VEGF-A) level may be useful. We determined tumor uptake of (89)Zr-bevacizumab, a VEGF-A-binding PET tracer, in mRCC patients before and during antiangiogenic treatment in a pilot study. METHODS Patients underwent (89)Zr-bevaciz...

Background: Metabolic tumour volume assessment using positron emission tomography (PET) may be of interest for both target volume definition in radiotherapy and monitoring response to therapy. It has been reported, however, that metabolic volumes derived from images of metabolic rate of glucose (generated using Patlak analysis) are smaller than those derived from standardized uptake value (SUV)...

We have studied the possible relationship between the immunohistochemical expression of p16 and the maximum standardized uptake value (SUV max) of F-18 fluorodeoxyglucose-positron emission tomography (F-18 FDGPET) in 49 patients with non-small cell lung cancer (NSCLC). Immunohistochemical negativity of p16 was verified in 71.4 % of the patients, higher in squamous cell carcinomas than in adenoc...