Successful ab initio folding of proteins with both -helix and -sheet requires a delicate balance among a variety of forces in the simulation model, which may explain that the successful folding of any / proteins to within experimental error has yet to be reported. Here we demonstrate that it is an achievable goal to fold / proteins with a force field emphasizing the balance between the two majo...

BACKGROUND We examined fertility-specific distress (FSD) and general distress by type of fertility barrier (FB). METHODS In a random sample telephone survey, 580 US women reported their fertility intentions and histories. Six groups of women were identified: (i) no FBs, (ii) infertile with intent, (iii) infertile without intent, (iv) other fertility problems, (v) miscarriages and (vi) situati...

Pallidal deep brain stimulation (DBS) is currently the most effective treatment for advanced, medically refractory dystonia. However, factors predicting clinical outcome are not well defined. We reviewed the clinical records of 39 consecutive patients with medically refractory primary dystonia who underwent pallidal DBS implants. Thirty-five patients were implanted bilaterally and four unilater...

In this issue of Pain, Gale et al. show that lower childhood intelligence is associated with increased risk of chronic widespread pain (CWP) later in life [2]. Although an association between chronic pain and cognitive ability has been shown before, the Gale et al. report is the first longitudinal study in a large general population cohort. Two important characteristics stand out in their study...

We study characteristics of the second significant digits of blockDCT coefficients computed from digital images. Following previous works on compression forensics based on first significant digits, we examine the merits of stepping towards significant digits beyond the first. Our empirical findings indicate that certain block-DCT modes follow Benford’s law of second significant digits extremely...

The original state-dependent fractional stress-dilatancy (FSD) equation for soils is developed based on the critical state lines (CSLs) with linear form. However, experimental evidences showed that CSLs of soil in p ′ –q and e–p planes could be both nonlinear as well due to significant material degradation. This note aims propose a unified FSD arbitrary types CSLs. Detailed derivations are prov...

Abstract Introduction Various agents have been tested to treat female sexual dysfunction (FSD), particularly Hypoactive Sexual Desire Disorder and Female Arousal Disorder, but only two, flibanserin bremelanotide, met any regulatory standards (US only), none is popular with patients or prescribers. Several more agents, e.g., sildenafil, testosterone, alprostadil, buspirone, bupropion trazodone, ...

The present work explains the development and validation of a simple, rapid and sensitive liquid chromatographic method for the simultaneous determination of antipyrine (ANT), carbamazepine (CBZ), furosemide (FSD) and phenytoin (PHTN). Chromatographic analysis was carried out by a reversed phase technique on a C18 column, using water pH 3.0 and 50:50 mixtures of methanol and acetonitrile (58:42...