Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is caused by biofilm-growing mucoid strains. Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy, and they can be treated by chronic suppressive therapy. New results from one small trial suggest that addition of oral ciprofloxacin to inhaled tobramycin may reduce lung inflammation. Clinica...

The optimum regimen for the treatment of cryptococcal meningitis in patients with AIDS is still not totally clear. The triazoles fluconazole and itraconazole are associated with response rates of 50%-60%. Amphotericin B appears to be associated with a more rapid clearance of organisms, and there are some data suggesting that initial therapy with amphotericin B is preferable to that with triazol...

ence with Legionella cavitary pneumonia is not yet extensive enough to allow for firm recommendations regarding either the nature or duration of therapy. Furthermore, our experience raises the question of need for long-term suppressive therapy for Legionella in AIDS patients, similar to that given for other multiple intracellular infections, such as toxoplasmosis and cytomegalovirus. The experi...

Antimicrobial therapy is the standard of care for the unusual man with true chronic bacterial prostatitis but does not have much of a role in the treatment of men with nonbacterial prostatitis. The fluoroquinolone antibiotics given for 2 to 4 weeks will cure about 70% of chronic bacterial infections of the prostate. If this treatment fails, the symptomatic manifestations of the infections can a...

ence with Legionella cavitary pneumonia is not yet extensive enough to allow for firm recommendations regarding either the nature or duration of therapy. Furthermore, our experience raises the question of need for long-term suppressive therapy for Legionella in AIDS patients, similar to that given for other multiple intracellular infections, such as toxoplasmosis and cytomegalovirus. The experi...

Lymphocytes obtained from nonimmuno deficient children treated with commercially available preparations of gammaglobulin failed to proliferate and to mature into plasma cells in vitro after stimulation with pokeweed mitogen. The influence of the treatment on lymphocyte functions varied according to the cell population considered. A T helper cell activity was detected in these patients but only ...

Seven AIDS patients who were receiving suppressive therapy for previously diagnosed cytomegalovirus (CMV) retinitis were offered treatment with protease inhibitors (PIs). Secondary prophylaxis for CMV was discontinued after 3 months of therapy with PIs if patients had >150 CD4 cells/mm3 and a human immunodeficiency virus (HIV) load of <200 copies/mL and if they were negative for CMV as determin...

OBJECTIVES The contribution of specific antiretroviral drugs to cognitive function in HIV-infected people remains poorly understood. Efavirenz (EFV) may plausibly cause cognitive impairment. The objective of this study was therefore to determine whether chronic EFV therapy is a modifier of neurocognitive and neurometabolic function in the setting of suppressive highly active antiretroviral ther...

In advanced HIV infection, the homeostatic balance between gastrointestinal indigenous bacteria and gut immunity fails and microbes are able to overcome the intestinal barrier and gain the systemic circulation. Because microbial translocation is not fully controlled by antiviral therapy and is associated with inefficient CD4+ reconstitution, we investigated the profile of translocating bacteria...

such prolonged therapy, significant relapse rates may still be obincreased to 400 mg/d and was gradually tapered 4 months later. served, even years after surgery. Suppressive fluconazole therapy After receiving treatment for 1 year, she is well, and no relapses may play an important role in the prevention of relapse; however, have occurred since therapy with fluconazole was discontinued. the op...