In this paper, we show, for the first time, the key link between scaffold architecture and latent heat evolution during the production of porous biomedical collagen structures using freeze-drying. Collagen scaffolds are used widely in the biomedical industry for the repair and reconstruction of skeletal tissues and organs. Freeze-drying of collagen slurries is a standard industrial process, and...

Mechanical stimulus has been identified for a long time as a key player in the adaptation of the musculo-skeletal tissues to their function. Mechanical loading is then an intrinsic variable to be considered when new developments are proposed in bone tissue engineering. By combining structural biomechanics and mechanotransduction aspects, a new paradigm is presented for bone tissue engineering. ...

This theoretical note aims at studying the role of reference points in generating unemployment volatility. For this purpose, I introduce the notion of reference points in a standard Mortensen-Pissarides model. I obtain two results. First, I find that the obtained model is similar to the one found by Pissarides (2009). Second, I show that the introduction of reference points can increase signifi...

This work is motivated by problems on simultaneous Diophantine approximation on manifolds, namely, establishing Khintchine and Jarńık type theorems for submanifolds of Rn. These problems have attracted a lot of interest since Kleinbock and Margulis proved a related conjecture of Alan Baker and V.G. Sprindžuk. They have been settled for planar curves but remain open in higher dimensions. In this...

Many tools for test generation already exist and are used in industry; others are under development or improvement to allow faster generation and more effective tests. Comparing testing tools permits to acquire in-depth knowledge of the characteristics of each tool and to discover its strong points and limitations. Thus, the analysis of different automatic test generation tools provides a preci...

In this article, we show the existence of at least three solutions to a Navier boundary problem involving the p(x)-biharmonic operator. The technical approach is mainly base on a three critical points theorem by Ricceri.

Background. Acupoint stimulation is popular for treatment of fibromyalgia though there is lack of comprehensive evaluation of current clinical evidence for its effect and safety. Objective. To systematically review the beneficial effects and safety of acupoint stimulation for fibromyalgia. Methods. We searched six electronic databases for randomized trials on acupoint stimulation for treatment ...

Adoption of evidence-based practice (EBP) is an increasingly advocated yet formidable challenge. Much work on EBP has implied simplistic solutions: if researchers would produce practice-relevant evidence-based approaches, practitioners would find, adopt, and use them. Blaming researchers for problems in supply, and practitioners for resistance in adoption, will only thwart progress at improving...

On the line and its tensor products, Fekete points are known to be the Gauss–Lobatto quadrature points. But unlike high-order quadrature, Fekete points generalize to non-tensor-product domains such as the triangle. Thus Fekete points might serve as an alternative to the Gauss–Lobatto points for certain applications. In this work we present a new algorithm to compute Fekete points and give resul...