A promising approach to the treatment of superficial human cancer is laser induced hyperthermia. A correct choice of the parameters used for the treatment planning should be based on modeling of both radiative transfer and transient heating of human tissues which will allow to predict the thermal conversions in the tumor. In this paper, we focus on the radiative transfer modeling which should b...

OBJECTIVES Glass-ceramic veneered zirconia is used for the application as fixed partial dentures. The aim of this investigation was to evaluate whether the heat treatment during veneering, the application of glass-ceramic for veneering or long term storage has an influence on the storage modulus of zirconia. METHODS Zirconia bars (Cercon, DeguDent, G; 0.5x2x20 mm) were fabricated and treated ...

5-hydroxytryptamine (5-HT) released in inflammatory tissues plays a pivotal role in pain hypersensitivity. However, it is not clear whether 5-HT2A receptors in the inflamed tissues mediate this effect. The present study investigated the contribution of 5-HT2A receptors in the periphery to chronic inflammatory pain. Complete Freund's adjuvant (CFA) was injected subcutaneously in the hindpaw of r...

introduction: the aim of this study was to compare the micro-shear bond strength of composite resin on superficial and deep dentin after conditioning with phosphoric acid and erbium-doped yttrium aluminum garnet (er:yag) laser. methods: thirty human molars were selected, roots were removed and crowns were bisected to provide a total of 60 half-crowns. specimens were ground to expose superficial...

Values for thermal enhancement and therapeutic gain are useful for deciding future directions of hyperthermia combined with other cancer therapy modalities. Evidence of thermal enhancement of effects on normal tissues is important as it indicates the need for dose modification. Specific values cannot be used generally to determine the degree of dose modification for clinical applications. A ran...

Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling. Like binding with the activators (P35 or P25), the phosphorylation of Cdk5 plays a critical role in Cdk5 activation. However, it is still unclear whether Cdk5 phosphorylation (p-Cdk5) contributes to pain hyperalgesia. The aim of our current study was ...

Small-diameter sensory neurons that are primarily nociceptors can be divided neurochemically into two populations: isolectin B(4) (IB(4))-positive nonpeptidergic neurons, and IB(4)-negative peptidergic neurons. It has been shown that IB(4)-positive neurons depend on glial-derived neurotrophic factor (GDNF), whereas IB(4)-negative neurons depend on NGF for survival during postnatal development (...