Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups for cross-linking to tumor-targeting ligands such as monoclonal antibodies, pep...

Background: Finding a suitable method for rapid, accurate and reliable estimation of absorbed dose has high priority in management of the radiation exposed persons. Shortly after radiation exposure, apoptosis is a major detriment in proliferative tissues such as the hematopoietic system. Therefore, quantification of apoptosis in these tissues could be useful for rapid estimation of radiation ex...

Iron oxide nanoparticles (INPs) have potential biological, biomedical and environmental applications. These applications require surface modification of the iron oxide nanoparticles, which makes it non-toxic, biocompatible, stable and non-agglomerative in natural and biological surroundings. In the present study, iron oxide nanoparticles (INPs) and chitosan oligosaccharide coated iron oxide nan...

Introduction Endothelial progenitor cells (EPC) are promising candidates for novel stem cell transplantation strategies to treat cardiovascular diseases. Within this study formations of vascular network structures with super paramagnetic iron oxide (SPIO) loaded EPCs were induced, which is an in vitro correlate of the vasculogenesis process [1]. The resulting endothelial network showed to be an...

in this research nickel zinc ferrite nanoparticles with composition of ni1-xznxfe2o4 (where x=0, 0.3, 0.7, 1) were synthesized by a sol-gel method at 600 °c for 5 hours. the structure of nanoparticles was studied using x-ray diffraction pattern. the lattice parameter of ferrite nanoparticles was calculated and indicates lattice constant of nanoparticles depend on zinc concentration. the crystal...

The purpose of this study was to synthesize biocompatible poly(2-hydroxyethyl aspartamide)-C16-iron oxide (PHEA-C16-iron oxide) nanoparticles and to evaluate their efficacy as a contrast agent for magnetic resonance imaging of lymph nodes. The PHEA-C16-iron oxide nanoparticles were synthesized by coprecipitation method. The core size of the PHEA-C16-iron oxide nanoparticles was about 5 to 7 nm,...

Introduction: Positive-contrast imaging of super paramagnetic iron oxide (SPIO)labeled cells avoids problems associated with negative contrast such as other signal voids and partial volume effects [1-7]. Many techniques offer 2D imaging with thick slices and long scan times. A fast 3D alternating repetition time (ATR) SSFP [8] method with reliable on-resonant suppression has recently been intro...

Androgen deprivation therapy (ADT) provides palliation for most patients with advanced prostate cancer (CaP); however, greater than 80% subsequently fail ADT. ADT has been indicated to induce an acute but transient destabilization of the prostate vasculature in animal models and humans. Human re-hydrated lyophilized platelets (hRL-P) were investigated as a prototype for therapeutic agents desig...

PURPOSE Cell-surface receptor-targeted magnetic iron oxide nanoparticles provide molecular magnetic resonance imaging contrast agents for improving specificity of the detection of human cancer. EXPERIMENTAL DESIGN The present study reports the development of a novel targeted iron oxide nanoparticle using a recombinant peptide containing the amino-terminal fragment of urokinase-type plasminoge...