We have previously shown (Sunkara et al., 1989; Taylor et al., 1991) that 6-o-butanoyl castanospermine (BuCast) was a 30-50-fold better inhibitor of HIV syncytia formation than castanospermine (Cast). Radiolabeled Cast and BuCast were used to study the uptake and metabolism of these compounds in cultured cells and in mice. BuCast was preferentially taken up by cells compared to Cast. Approximat...

Drosophila larvae exhibit klinotaxis when placed in a gradient of temperature, chemicals, or light. The larva samples environmental stimuli by casting its head from side to side. By comparing the results of two consecutive samples, it decides the direction of movement, appearing as a turn proceeded by one or more head casts. Here by analyzing larval behavior in a light-spot-based phototaxis ass...

Abstract BioHEAs, specifically designed high entropy alloy (HEA) systems for biomedical applications, represent a new era biometals. However, recent challenges are (1) the poor shape customizability, and (2) inevitable severe segregation due to intrinsic fact that HEA is an ultra-multicomponent system. To achieve customization suppression of elemental simultaneously, we used extremely cooling r...

Myostatin (MSTN) is an inhibitor of skeletal muscle growth, and a mutation in the gene coding region leads to increased muscling. Calpastatin (CAST) is a specific inhibitor of the ubiquitous calcium-dependent proteases, µ-calpain and m-calpain, found in mammalian tissues. In this study, genomic DNA was extracted from Zandi sheep blood samples. Gel monitoring and spectrophotometer methods were u...

an h-magic labeling in a h-decomposable graph g is a bijection f : v (g) ∪ e(g) → {1, 2, ..., p + q} such that for every copy h in the decomposition, σνεv(h) f(v) +  σeεe(h) f(e) is constant. f is said to be h-e-super magic if f(e(g)) = {1, 2, · · · , q}. a family of subgraphs h1,h2, · · · ,hh of g is a mixed cycle-decomposition of g if every subgraph hi is isomorphic to some cycle ck, for k ≥ ...

to investigate effects of different super absorbent polymer and animal manure ratios on the quantitative and qualitative characteristics of soybean under drought stress, a split plots experiment was conducted based on randomized complete block design with three replications in marvdasht, iran in 2009. main factor included of irrigation with 50, 100 and 150 mm evaporation from pan class a and su...

We report that neuronal overexpression of the endogenous inhibitor of calpains, calpastatin (CAST), in a mouse model of human Alzheimer's disease (AD) β-amyloidosis, the APP23 mouse, reduces β-amyloid (Aβ) pathology and Aβ levels when comparing aged, double transgenic (tg) APP23/CAST with APP23 mice. Concurrent with Aβ plaque deposition, aged APP23/CAST mice show a decrease in the steady-state ...

In order to ensure the safety and stability of existing old masonry structure houses in process dewatering excavation super deep foundation pit subway, support form a water stop curtain combined with bored cast-in-place piles internal is adopted, rotary jet grouting are constructed around houses, sleeve valve pipes embedded, soil house grouted strengthened. The deformation building analyzed by ...

subluxation of the proximal interphalangeal joint (pipj or pastern joint) is an uncommon condition that occurs in the forelimb or hindlimb. thoroughbred racehorses rarely show dorsal pastern subluxation (thoroughbred ringbone) secondarily to an injury to the soft tissues supporting the fetlock. a 4-year-old thoroughbred mare was presented with signs of lameness, swelling of the dorsal aspect of...

background: creating a socket with proper fit is an important factor to ensure the comfort and control of prosthetic devices. several techniques are commonly used to cast transtibial stumps but their effect on stump shape deformation is not well understood. this study compares the dimensions, circumferences and volumes of the positive casts and also the socket comfort between two casting method...