A new series of fluorinated quinoline -1,4-dithiones 3(a-f) were obtained by the treatment 3-aryl-2-hydrazino-quinolines 1(a-f) with isobenzo furan-1,3-dithione 2 in presence p- toluene sulphonic acid (PTSA) solid state at room temperature as one pot. All products are monitored TLC and isolated GC furthermore confirmed spectral analysis.

Immunological studies have shown an increased lymphocyte reactivity in patients with early stage bladder cancer and individuals with pre-stage T1 exposed to bladder carcinogens (2-naphthylamine and industrial 1-naphthylamine containing 4-8% 2-naphthylamine) before 1952-that is, those at high risk of developing bladder cancer. Because of the close chemical similarity of Tobias acid (2-naphthylam...

Aluminium phthalocyanines substituted to different degrees with hydrophilic sulphonic acid and hydrophobic phthalimidomethyl groups were investigated in vivo as new agents for the photodynamic therapy of malignant tumours. Parameters studied included the photodynamic action on EMT-6 mammary tumours in BALB/c mice, the therapeutic window and the potential for direct cell killing, assayed via an ...

Three sulphonic acid-doped polyanilines were synthesized through chemical oxidation at low temperature (0-5 C) and potential of these polymers as sensing agent for O2 gas detection in terms of fluorescence quenching was studied. Sulphuric acid, dodecylbenzene sulphonic acid (DBSA) and camphor sulphonic acid (CSA) were used as doping agents. All polymers obtained were dark green powder. Polymers...

The dimeric enzyme creatine kinase (EC 2.7.3.2) from rabbit muscle has a reactive thiol group on each subunit, modification of which by iodoacetate or iodoacetamide leads to inactivation of the enzyme (Watts, 1973). It had been previously shown (Price & Hunter, 1976) that when the enzyme is treated with iodoacetate or some other reagents in the presence of the 'transition-state analogue' comple...

Manuka honey (MH, 5g/kg) provided protection against trinitro-benzo-sulphonic acid induced colonic damage. Combination therapy (MH+sulfasalazine) also reduced colonic inflammation and all the biochemical parameters were significant compared to control and MH alone treated group. Combination therapy showed additive effect of the MH which restored lipid peroxidation and improvement of antioxidant...