نتایج جستجو برای: sulphasalazine
تعداد نتایج: 503 فیلتر نتایج به سال:
OBJECTIVE To determine the predictive value of shared epitope alleles for response to treatment in patients with rheumatoid arthritis. METHODS Patients from our previously published triple DMARD study were tested for the presence of shared epitope alleles (DRB1 *0401, 0404/0408, 0405, 0101, 1001, and 1402). Patients who were shared epitope positive were then compared with those who were negat...
background: the antifertility effect of ampicillin (amp, 40 mg/kg) and sulphasalazine or salicylazosulfapyridine (sasp, 300,450 and 600 mg/kg) in male rats has been reported earlier. the combination of amp and sasp is generally used in certain pathological conditions, but the combined effect of these two drugs on the fertility is not clear. so, the aim of this study was to investigate the antif...
Mesalazine has structural similarities to aspirin and phenacetin and is nephrotoxic when given intravenously in high doses to rats. A number of cases of nephrotoxicity has been reported recently in patients taking oral mesalazine. Sensitive indicators of renal function in a group of patients maintained on long term, delayed release mesalazine and a comparable group on sulphasalazine have been s...
OBJECTIVE To assess the effectiveness, safety and cost implications of leflunomide treatment for rheumatoid arthritis. DESIGN Systematic review. SETTING Four trials retrieved from Medline, Embase, the Cochrane Library, Econlit, HMIC (Dhdata), HMIC (Helmis), HMIC (King's Fund Database) and Best Evidence3. MAIN OUTCOME MEASURES Efficacy measures (including tender joint counts, swollen joint...
BACKGROUND Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow relea...
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