It has been found that, like Atabrine, the phenothiazine tranquilizers promazine, chlorpromazine, promethazine, levopromethazine, and Stelazine; the antidepressants (dibenz-azepine and dibenzocycloheptene derivatives) Tofranil, Pertofrane, cyclobenzaprine, Elavil, protriptyline, and 3-chlorodibenzocycloheptene; and the acridine derivatives acridine orange, acriflavin, SKF no. 16214-A2, SKF no. ...

Kasuya, Morimasa (Nagoya University School of Medicine, Nagoya, Japan). Transfer of drug resistance between enteric bacteria induced in the mouse intestine. J. Bacteriol. 88:322-328. 1964.-Transfer of multiple drug resistance in the intestines of germ-free and conventional mice was studied with strains of Shigella, Escherichia, and Klebsiella. The transfer experiment was carried out under antib...

In an earlier paper the therapeutic effectiveness of sulfathiazole used during the acute stages of Sonne bacillary dysentery was demonstrated.5 However, it was shown also that sulfonamide therapy did not curtail the period during which the Sonne organism could be recovered by rectal cultures. Actually, there appeared to be statistical evidence that this period was prolonged when compared with u...

The usefulness of sulphaguanidine in the treatment of cholera, especially in its early stage, was discussed in a previous paper published by the author (1945). The absorbable sulphonamides however do not appear to have been as yet much tried for the treatment of this disease. Hardy et al. (1943) and Hardy and Cummins (1943) published two papers indicating very good curative action of sulphadiaz...

Thiazoles displayed broad range of biological activities and found in many potent biologically active molecules such as Sulfathiazol (antimicrobial drug), Ritonavir (antiretroviral drug), Abafungin (antifungal drug) and Tiazofurin (antineoplastic drug). So far, modifications of the thiazole ring have proven highly effective with improved potency and lesser toxicity. The present review highlight...

Protein-protein interactions play crucial roles in numerous biological processes. However, it is still challenging to evaluate the protein-protein interactions, such as antigen and antibody, in the presence of drug molecules in physiological liquid. In this study, the interaction between bovine serum albumin (BSA) and rabbit anti-BSA was investigated using atomic force microscopy (AFM) in the p...

Effects of copper (Cu) and aluminum (Al) on the adsorption of sulfathiazole (STZ) and tylosin (T) to peat and soil were investigated using a batch equilibration method. Results show that Cu suppressed STZ adsorption onto peat and soil at pH < 5.0 because of the electrostatic competition, while increased STZ adsorption at pH > 5.0 due to the formation of STZ-Cu complexes and/or Cu bridge. In con...

O presente trabalho descreve a aplicação bem sucedida da microextração em sorvente empacotado e cromatografia líquida com detecção de arranjo de diodos (MEPS/LC-DAD) para a determinação simultânea das sulfonamidas (sulfacetamida, sulfadiazina, sulfatiazol, sulfametazina sulfametoxipiridazina e sulfametoxazol) em amostras de ovos. As variáveis MEPS (pH da amostra, número de ciclos aspirar/dispen...

Anderson, T., Cooper, E. D., Cairns, J. G. and Brown, D. R. (1939) Lancet, 2, 776. Brown, J. W. and Finland, M. (1939) Amer. J. med. Sci. 197, 369. Bullowa, J. G. M. and Wilcox, C. (1935) Arch. intern. Med. 55, 558. Cruickshank, R. (1933) Lancet, 1, 563, 621 and 680. Fleming, A. (1938) Ibid, 2, 74. Gaisford, W. F. (1939) Proc. R. Soc. Med. 32, 1070. Horsfall, F. L., Jr., Goodner, K., MacLeod, C...

The problem of resistance to sulfonamide therapy1 in male gonorrhea is well known. Cox (1) states that, in varying degrees, clinical resistance is found in approximately 25 per cent of cases treated with sulfadiazine or sulfathiazole. More recently, the incidence of resistance has risen to approximately 50 per cent of cases admitted to the Boston Dispensary (2). This resistance is manifested ei...