A click chemistry approach based on the reaction between alkynylflavins and mono(6-azido-6-deoxy)-β-cyclodextrin has proven to be a useful tool for the synthesis of flavin-cyclodextrin conjugates studied as monooxygenase mimics in enantioselective sulfoxidations.

The solubilizing effect of β-cyclodextrin on fingolimod, a new generation immunosuppressant, is studied for the first time. A possible 20× increase in solubility fingolimod due to penetration hydrophobic fragment drug molecule into macrocyclic cavity cyclodextrin shown. Data driven 1H NMR spectroscopy and computer modeling suggest configuration resulting inclusion complexes. constant complex’s ...

Pioglitazone is a thiazolidinedione derivative used for the treatment of type 2 diabetes. The drug's poor aqueous solubility and slow dissolution rate are the main causes of its limited therapeutic action in some cases. The aim of the present study is to formulate a more soluble product of pioglitazone at physiological pH. The potential interaction of pioglitazone with cyclodextrins and water-s...

The molecularly imprinted polymer (MIP) based on methacrylic acid functionalized β-cyclodextrin (MAA-β-CD) monomer was synthesized for the purpose of selective recognition of benzylparaben (BzP). The MAA-β-CD monomer was produced by bridging a methacrylic acid (MAA) and β-cyclodextrin (β-CD) using toluene-2,4-diisocyanate (TDI) by reacting the -OH group of MAA and one of the primary -OH groups ...

Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole-HPBCD complex was incorporated into an ion-sen...

Disulfiram (DS) has an excellent anti-viral activity; however, its low water-solubility and first-pass metabolism are limiting clinical applications. Cyclodextrins (CDs) have been used as solubility enhancers carriers of DS proposed for inhalation to treat SARS-CoV-19. Two types CDs (hydroxypropyl β-cyclodextrin sulfobutyl ether β-cyclodextrin) were form inclusion complexes wi...

Poor aqueous solubility of anticancer drug, albendazole (ABZ), prevents parenteral application. Here, we demonstrate how to increase the aqueous solubility of ABZ to 6- 8 mg/ml using sulfobutylether - β-cyclodextrin (SBE-β-CD) or Hydroxypropyl- β-cyclodextrin (HP- β-CD) by manipulation of complexation parameters such as the physical state of ABZ (ionized in acetic acid), the concentration of io...

The influence of oligosaccharides (α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin), a polysaccharide, sodium hyaluronate (NaHy), on the diffusion aqueous solutions cobalt chromium chlorides has been investigated. Cobalt are constituents metal alloys for biomedical use, including dental prostheses. Thus, release these ions in human body can lead to harmful biological effects. interaction with...

In this research, we report on the synthesis of mesoporous silicas with various quantities of immobilized oligosaccharide groups and different pore ordering degree. The hydrothermal co-condensation of tetraethyl orthosilicate and β-cyclodextrin-containing organosilane in the presence of cetyltrimethylammonium bromide template was employed. The purpose of this investigation was to show the oppor...

The influence of organic additives, β-cyclodextrin, HEDTA, L-aspartic acid and L-glutamic acid on crystal growth of calcium carbonate via vapour diffusion method has been investigated. In the absence of additive, regular rhombohedral calcium carbonate crystal habit resulted. Whereas in presence of additive, calcite with truncated, aggregated rhombohedral sub crystals and elongated hexagonal mor...