Sheep are subjected to a multitude of psychological and environmental stressors that cause decreased productivity, increased disease and hence to poorer welfare. The weaning is one of the most stressful procedures for all lambs not only in terms of the dam-lamb relationship, but also because of its potential effect on the health of lamb. In numerous studies have been discussed the effects of di...

Twenty-seven crosses of mice derived from three random-mating, unselected strains (SWO, J. PGH) with 16 matings/pureline or cross were cohabited continuously and monogamously for a 365-d reproduction period to evaluate lifetime reproductive performance of the parents. Data from 3,249 litters born (2,792 surviving to weaning) were analyzed to study the effects of parity (number of litters) and t...

BACKGROUND An increasing number of stroke patients have to be supported by mechanical ventilation in intensive care units (ICU), with a relevant proportion of them requiring gradual withdrawal from a respirator. To date, weaning studies have focused merely on mixed patient groups, COPD patients or patients after cardiac surgery. Therefore, the best weaning strategy for stroke patients remains t...

Lead (Pb) is found to impair cognitive function. Synaptic structural plasticity is considered to be the physiological basis of synaptic functional plasticity and has been recently found to play important roles in learning and memory. To study the effect of Pb on spatial learning and memory at different developmental stages, and its relationship with alterations of synaptic structural plasticity...

Spontaneous breathing trials (SBTs) are among the most commonly employed techniques to facilitate weaning from mechanical ventilation. The preferred SBT technique, however, is still unclear. To clarify the preferable SBT (T-piece or pressure support ventilation [PSV]), we conducted this systematic review. We then searched the MEDLINE, EMBASE, SciELO, Google Scholar, CINAHL, ClinicalTrials.gov, ...

Weaning stress caused marked changes in intestinal structure and function. Transforming growth factor-β1 (TGF-β1) and canonical Smads signaling pathway are suspected to play an important regulatory role in post-weaning adaptation of the small intestine. In the present study, the intestinal morphology and permeability, developmental expressions of tight junction proteins and TGF-β1 in the intest...

BACKGROUND Many years of bracing represent a burden to the patients. Early weaning may be the result of poor compliance, but may also be planned in patients with a long expected treatment time and a reduced stable primary curve during bracing. The aim of the present cohort study was to compare curve size, health related quality of life and surgical rates at long-term follow-up after ordinary br...

AIMS AND OBJECTIVES To examine the elements of the intensive care environment and consider the impact on nurses' involvement in decision-making when weaning from mechanical ventilation. BACKGROUND Optimal management of difficult to wean patients requires the dynamic collaboration of all clinicians and the contribution of their knowledge and skills. The introduction of weaning protocols has in...

OBJECTIVE To evaluate the clinical relevance of the weaning from mechanical ventilation classification system derived from the 2005 international consensus conference, in patients who receive mechanical ventilation for more than 48 hours, and evaluate its correlation with prognosis. METHODS We conducted a retrospective cohort study in a 12-bed intensive care unit (ICU) in a teaching hospital....