During the past four years, the research of new synthetic methodologies for the rapid construction of enantiomerically pure substituted indole has had a fruitful and important growth. This research line continues to produce stunning arrays of enantioselective technologies either metal or organocatalyzed. Thus, an update of our previous review (Chem. Soc. Rev., 2010, 39, 4449-4465) has become ne...

Indoles constitute a widely occurring functional group in nature and are present an extensive number of bioactive natural products medicinally important compounds. As result, exponential increases the development novel methods for formation indole core along with site-specific indoles have been established. Conventional synthesis getting replaced green involving ionic liquids, water as solvent,...

The chromogenic reagent described has been tested with seventy-nine indole derivatives and found to be very sensitive and indole-specific. The lower limit of detection on silica gel thin-layer plates was between 25 and 50 ng for most indoles. Phenols and hydroxy-, and amino-benzoic acids, hydroxy-, and methoxy-cinnamic acids did not yield chromophores with the exception of p-amino-benzoic acid ...

The Fischer indole synthesis is perhaps the most powerful method for indole preparation, but it often suffers from low regioselectivities with unsymmetric aliphatic ketone substrates and strong acidic conditions and is not suitable for α,β-unsaturated ketones. In this article, we disclose an efficient synthesis of N-protected indoles from N-arylhydroxamic acids/N-aryl-N-hydroxycarbamates and a ...

Photo-physical properties of bromo-indolylmaleimide (IM-Br), indole-succinimide (IS), and their anions were theoretically investigated compared with the previous theoretical result for indolylmaleimide (IM) [Phys. Chem. Chem. Phys., 2010, 12, 9783]. The energies for the electronic excited states as well as the ground states were computed for these molecules using the multi-reference perturbatio...

A facile method for the synthesis of paraand meta-substituted bis(indole)-1,2,4-triazinones is presented. Our approach to access these triazinones involves a cyclocondensation reaction between amidrazone and ketoester functionalities. The structures of these interesting compounds were established unambiguously by X-ray crystallography. 2005 Elsevier Ltd. All rights reserved. Over the past sever...

Indolylimidazole ring-containing natural and synthesized compounds have shown vast biological activities. These indolylimidazole contain both indole imidazole rings. The structure resembling 1a-1d 2a-2d were by a green efficient one-pot four components condensation of indole-3-carbaldehyde, benzil, ammonium-acetate, substituted amines under microwave irradiation using Amberlyst A-15 as recyclab...