Aim: A variety of Paracetamol derivatives as mannich bases were prepared through mannich reaction by reacting Paracetamol as compound containing active hydrogen, substituted benzaldehyde, morpholine as secondary amine compound and small amount of conc. HCl as catalyst. A simplistic one-pot method under mild conditions has been developed for the synthesis of all the compounds and they were chara...

Abstract: Background: From the wide range of previous literature studies indicated that thiazolidinedione’s reacts with substituted benzaldehydes undergoes knoevenagel condensation gives respective arylidene derivatives. In our attempt all titled compounds were designed and developed by replacement furan- 2-aldehyde, so furan moiety was introduced in molecule. Materials Methods: 5-[(furan-2-yl)...

Rapid and catalyst-free hydrazone ligation reaction between ortho-halobenzaldehyde derivatives and peptide/protein hydrazides was observed at neutral pH and room temperature. 2-Chlorobenzaldehyde exhibited the fastest reaction and highest conversion rates among the series of ortho-halobenzaldehydes. The resulting hydrazone-containing bioconjugation products were also found to be fairly stable u...

an efficient construction of 2-(n-arylamino)benzaldehydes and n-aryl-3,10-dihydroacridin-1(2h)-one derivatives starting from 2- hydroxybenzaldehydes has been developed. the synthesis of n-aryl-3,10-dihydroacridin-1(2h)-ones is based on the knoevenagel condensation of dimedone to various 2-(n-arylamino)benzaldehydes, followed by an intramolecular enamination in the presence of 20 mol% of nanocry...

Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolcular [1,5]-hydride shift/isomerization reaction has been realized, using the inherent reducing power of 3-pyrrolines. A series of N-arylpyrrole containing amines are obtained in high yields.