Little is known about longitudinal development of the peri-implant subgingival microbiome and cytokine production as a new sulcus forms after dental implant placement. Therefore, the purpose of this observational study was to evaluate simultaneous longitudinal changes in the oral microbiome and cytokine production in the developing peri-implant sulcus compared to control natural teeth. Four and...

Murine monoclonal antibodies specific for Treponema denticola serovar C were produced and characterized in this study. An immunoassay was then developed by using these monoclonal antibodies, and the T. denticola serovar C antigen content of subgingival plaque was quantitated for samples taken from patients with periodontitis and healthy volunteers. The human subgingival plaque samples were grou...

A survey was conducted of 423 crown margins that were divided into 355 subgingival margins and 68 supragingival margins. The plaque index, gingival bleeding, and recession surrounding the artificial crown were recorded and compared to the unprepared contralateral tooth. Gingival tissues tended to bleed 2.42 times more frequently with subgingival margins and have a 2.65 times higher chance of gi...

Both oral cavity and subgingival pocket are ecological niches conducive to hosting microorganisms that may act as opportunistic pathogens, such as Staphylococcus aureus and especially methicillin-resistant Staphylococcus aureus (MRSA). Early detection of MRSA is a matter of concern to Public Health. The aim of our study was to determine phenotypic and genotypic detection of methicillin resistan...

BACKGROUND The commensal intestinal microflora has important metabolic and perhaps also immune modulatory functions. Evidence has accumulated that the microflora plays a role in the pathogenesis of inflammatory bowel disease. Therefore, there is a growing interest in the intestinal microflora and its interaction with the host. Presumably, this interaction takes place at the mucus layer. In this...

Received: 25 June 2008 Accepted: 19 November 2008 Abstract: Objective: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV) and Epstein Barr virus (EBV-1) seem to play a part in the pathogenesis of human periodontitis. The aim of this investigation was to evaluate the subgingival presence of HCMV and EBV in patients with aggressive periodontitis (AgP). ...

The supragingival plaque control need has been sustained by the concept of the periodontal disease as an opportunistic infection. This concept relies on the fact that the supragingival biofilm has been proven to be essential for the establishment of the subgingival biofilm, this opportunity arising through a retro-feeding process between the supragingival biofilm formation and maturation and th...

BACKGROUND The present study is designed to evaluate the clinical effects of pulsated subgingival irrigation with tetracycline and spiramycin. MATERIALS AND METHODS Ten patient diagnosed chronic periodontitis were included in the present study. Each patient is assigned to be irrigated with saline (placebo) (Group A), tetracycline HCl at 0.5% concentration (Group B), and 0.5% spiramycin (Group...