A nthracyclines are highly effective in the treatment of childhood malignancies, but are potentially cardiotoxic at all dose ranges. Early studies suggested that as many as 65% of acute lymphoblastic leukaemia (ALL) survivors have subclinical abnormalities of left ventricular (LV) systolic function at medium term follow up. More recent reports have shown that the prevalence of cardiac abnormali...

Introduction Left ventricular (LV) twist is believed to store potential energy and plays an important role in generating diastolic suction. Recent advances in echocardiography techniques have allowed quantification of LV twist. The aim of the present study was to compare LV twist and torsion in healthy human subjects determined by velocity vector imaging (VVI) and tissue Doppler imaging (TDI) a...

The relationship between circadian blood pressure (BP) variations and the extent of subclinical cardiac organ damage is still debated. In a general population, we investigated the association of night-to-day BP fall, as well as nocturnal BP level (mean and lowest values), with left ventricular (LV) hypertrophy and the value of both BP parameters in predicting new-onset LV hypertrophy. Office BP...

AIM Our objective was to evaluate regional systolic myocardial contraction properties along the long and short axes of the left ventricle (LV) in patients with isolated LV non-compaction (IVNC). METHODS AND RESULTS Pulsed tissue Doppler imaging (TDI) was used to record myocardial velocities along these axes in 25 patients with IVNC (10 asymptomatic-LV ejection fraction [LVEF] > or = 50%; 15 s...

In patients at risk of intraventrcular thrombosis, the benefits of chronic anticoagulation therapy need to be balanced with the pro-hemorrhagic effects of therapy. Blood stasis in the cardiac chambers is a recognized risk factor for intracardiac thrombosis and potential cardiogenic embolic events. In this work, we present a novel flow image-based method to assess the location and extent of intr...

BACKGROUND Poor glycemic control is associated with impaired left ventricular (LV) diastolic function in patients with type 2 diabetes mellitus (T2DM). Inappropriate LV mass increase and accelerated aortic stiffening were suggested to participate on deterioration of diastolic function. The present study investigated the inter-relationships between glycemic control, early diastolic and systolic ...

Abstract Background The independent role of pericardial adipose tissue (PAT) as an ectopic fat associated with cardiovascular disease (CVD) remains controversial. This study aimed to determine whether PAT is left ventricular (LV) structure and function other markers general obesity. Methods We studied 2471 participants (50.9 % women) without known CVD from the Korean Genome Epidemiology Study, ...

OBJECTIVE Several studies have shown that left ventricular (LV) dysfunction is increased in individuals with diabetes. However, there are scarce data about LV function in prediabetics. This study assessed the early changes in LV diastolic and systolic myocardial function in normotensive prediabetics using tissue Doppler echocardiography (TDE). SUBJECTS AND METHODS We evaluated 94 patients wit...

The purpose of our study was to evaluate the left ventricular (LV) and left atrial (LA) function in patients with gout. A total of 173 patients underwent a comprehensive Doppler-echocardiography examination. Participants were divided into four groups-Stage 0: control (n = 35), Stage I: asymptomatic hyperuricemia (n = 30), Stage II: gouty arthritis without tophi (n = 58), and Stage III: tophaceo...

BACKGROUND Although arrhythmogenic right ventricular dysplasia (ARVD) predominantly affects the right ventricle (RV), genetic/molecular and histological changes are biventricular. Regional left ventricular (LV) function has not been systematically studied in ARVD. METHODS AND RESULTS The study population included 21 patients with suspected ARVD who underwent evaluation with MRI including tagg...