introduction: endurance training has significant effects on the renewal of heart tissue, including myosin heavy chain (mhc) proteins. on the other side, purine-rich element-binding protein β (purb) decreases the &alphamhc; gene expression. the aim of this study was to determine the impact of exercise endurance training on purb gene expression in the heart of wistar rats. methods: fourteen rats ...

background: assessment of myocardial function is essential in heart disease, but in regard to systolic and diastolic functions such evaluation has limitation. ejection fraction is difficult to assess in abnormally-shaped ventricles, and diastolic inflow velocity pattern may be fused because of tachycardia.   objective: a myocardial performance index (mpi) or tei index has been developed for adu...

spontaneous coronary artery dissection (scad) is a rare condition that can result in unstable angina, acute myocardial infarction, and sudden death. this condition may occur particularly in women during late pregnancy and in the postpartum period. we present the case of a 33-year-old african american woman, who had spontaneous left anterior descending coronary artery (lad) dissection two weeks ...

conclusions: this study showed acceptable sensitivity and specificity of qtcd and qtd in comparison to lvmi; it seems that standard ecg can be used for early diagnosis of cardiac involvement in asymptomatic patients with thalassemia major. patients and methods: in a case-control study, 60 patients older than ten years of age with thalassemia major who received regular blood transfusion and iron...

Osteoprotegerin, a member of the tumor necrosis factor receptor superfamily, has pleiotropic effects on bone metabolism, endocrine function, and the immune system. Myocardial expression and circulating levels of osteoprotegerin are increased in heart failure. The relationship between osteoprotegerin levels in the general population and indices of left ventricular structure and function is unkno...

background: the cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. this study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. methods: five groups (7 each) of male sprague-dawley rats, including a control group, a diabetes (induced by streptozocin and nicotinamide)...