#### Notable in Neurology This Week This issue features an article that investigates the association of white matter hyperintensities on MRI with disease variables patients behavioral-variant frontotemporal dementia and Alzheimer disease; another compares benefits limitations whole genome sequencing to exome or multigene panel for diagnosis developmental epileptic encephalopathies. A featured ...

OBJECTIVE Many stroke survivors experience poststroke spasticity and the related inability to perform basic activities, which necessitates patient management and treatment, and exerts a considerable burden on the informal caregiver. The current study aims to estimate burden, productivity loss, and indirect costs for caregivers of stroke survivors with spasticity. METHODS Internet survey data ...

Objective Startling acoustic stimulation (SAS), via activation of reticulospinal (RS) pathways, has shown to increase muscle strength in healthy subjects. We hypothesized that, given RS hyperexcitability in stroke survivors, SAS could increase muscle strength in stroke survivors. The objective was to quantify the effect of SAS on maximal and sub-maximal voluntary elbow flexion on the contralesi...

BACKGROUND AND PURPOSE Memory impairment is a predictor and a consequence of stroke, but memory decline is common even in healthy elderly individuals. We compared the long-term trajectory of memory functioning before and after stroke with memory change in stroke-free elderly individuals. METHODS Health and Retirement Study participants aged 50 years and older (n=17 340) with no stroke history...

BACKGROUND AND PURPOSE Health-related quality of life (HRQoL) data are scarce from unselected populations. The aims were to assess HRQoL at 2 years poststroke, to identify determinants of HRQoL in stroke survivors, and to identify predictors at stroke onset of subsequent HRQoL. METHODS All first-ever cases of stroke in a population of 306 631 over a 1-year period were assessed. Stroke severit...

OBJECTIVES To investigate the prevalence of isolated urinary and fecal incontinence and double incontinence in community-living stroke survivors and to assess the degree of soiling. DESIGN Community-based postal survey. SETTING Leicestershire, United Kingdom. PARTICIPANTS Sixty-four thousand seven hundred forty-nine community-dwelling residents (aged > or = 40) were randomly selected from...

Background A significant factor in impaired movement caused by stroke is the inability to activate muscles independently. Although the pathophysiology behind this abnormal coactivation is not clear, reducing the coactivation could improve overall arm function. A myoelectric computer interface (MCI), which maps electromyographic signals to cursor movement, could be used as a treatment to help re...

Background: Stroke is a public health concern, and the emergence of COVID-19 virus has made continuation social support/rehabilitation groups for stroke survivors difficult. Many have been required to self-isolate 12 weeks or more, according government rules regulations. This led use innovative technological platforms (eg Zoom) delivering rehabilitation activities through ‘life after stroke’ gr...

Coordinated reaching requires continuous interaction between the efferent motor output and afferent feedback; this interaction may be significantly compromised following a stroke. The authors sought to characterize how survivors of stroke generate continuous, goal-directed reaching. Sixteen survivors of stroke completed functional testing of the stroke-affected side and a continuous reaching ta...