Progressive pancreatic β cell failure underlies the transition of impaired glucose tolerance to overt diabetes; endoplasmic reticulum (ER) stress expedites β cell failure in this situation. ER stress can be elicited by lipotoxicity and an increased demand for insulin in diabetes. We previously reported that the lipid droplet protein perilipin 2 (PLIN2) modulates lipid homeostasis in the liver. ...

AIMS Oxidative stress is present in and contributes to calcification of the aortic valve, but the driving factors behind the initiation of valve oxidative stress are not well understood. We tested whether the valve endothelium acts as an initiator and propagator of oxidative stress in aortic valve disease. METHODS AND RESULTS Calcified human aortic valves showed side-specific elevation of sup...

Drought is one of the major stress factors reducing cereal production worldwide. There is ample evidence that the mineral nutrient status of plants plays a critical role in increasing plant tolerance to different biotic and abiotic stresses. In this regard, the important role of various nutrients e.g., potassium (K) or silicon (Si) in the mitigation of different stress factors, such as drought,...

background: the effects of aqueous extract of fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight on alloxan-induced toxicity was investigated in wistar rats. methods: in total, 35 rats of both sexes (132.80±7.22g) were randomized into five groups (a-e): animals in group a received 0.5 ml of distilled water orally on daily basis for 15 days while the alloxanized rats in group...

This paper studies the effect of various mitigation loop configurations namely: single horizontal mitigation loop (two conductors), two separate horizontal mitigation loops (four conductors) and single vertical mitigation loop (two conductors), on the magnetic field produced by 220 kV double-circuit overhead transmission line. Also, in this paper a further reduction in the magnetic field is ach...

Small jobs, that are typically run for interactive data analyses in datacenters, continue to be plagued by disproportionately long-running tasks called stragglers. In the production clusters at Facebook and Microsoft Bing, even after applying state-of-the-art straggler mitigation techniques, these latency sensitive jobs have stragglers that are on average 8 times slower than the median task in ...

Dehydrins (DHNs) as a member of late-embryogenesis-abundant (LEA) proteins are involved in plant abiotic stress tolerance. Two dehydrins PpDHNA and PpDHNC were previously characterized from the moss Physcomitrella patens, which has been suggested to be an ideal model plant to study stress tolerance due to its adaptability to extreme environment. In this study, functions of these two genes were ...

The agriculture sector has great potential to contribute to the mitigation of greenhouse gas emissions through changes in agricultural management and land use. However, the technical potential for agricultural mitigation has yet to translate into actual emission reductions due to considerable constraints to the generation of emission offsets through agricultural projects. These constraints incl...

An experimental approach to road mitigation that maximizes inferential power is essential to ensure that mitigation is both ecologically-effective and cost-effective. Here, we set out the need for and standards of using an experimental approach to road mitigation, in order to improve knowledge of the influence of mitigation measures on wildlife populations. We point out two key areas that need ...

Melatonin, a pleiotropic signal molecule, has been shown to play important roles in the regulation of plant growth, development, and responses to environmental stresses. Since a few species have been investigated to unveil the effect of exogenous melatonin on salt stress, the underlying mechanism of melatonin-mediated salt stress tolerance in other plant species still remains largely unknown. I...