to evaluate the acute effect of lovastatin on diabetic endothelial dysfunction, we examined this effect on the aortic rings of streptozotocin-diabetic rats. the endothelial function was assessed in aortic rings isolated from diabetic rats, 12 weeks after treatment with streptozotocin (45 mg/kg, i.p.). the concentration-response curve to acetylcholine (ach) in the aortic rings precontracted with...

in india, the occurrence of diabetes mellitus is on increase and needs to be addressed properly. herbal remedies are considered most suitable for the management of type 2 diabetes due to their traditional acceptability and availability, low costs, and fewer side effects. traditionally bauhinia tomentosa l. (family- fabaceae) is used in the treatment of diabetes in india. aqueous extract and alc...

introduction: due to the relation between structure and function of renal glomeruli, the study of glomeruli is very important to the understanding of initiation and progression of diabetic glomerulopathy. it seems that glomeruli disappear during the course of diabetic nephropathy without leaving recognizable corpuscles. this study was aimed to show diabetes mellitus effects on changes in renal ...

Daily fat and sugar intake has increased in Japan, while total energy decreased. However, the number of type 2 diabetes mellitus patients increased, this often causes renal injury characterized by autophagic vacuoles. Although many studies with comparisons high or versus a normal macronutrient balanced diet have been reported, there are few that equalized calorie body weights. In current study,...

1. Microsomal prostaglandin synthesis and tissue prostaglandin concentrations in the kidneys of rats made diabetic by pretreatment with alloxan or streptozotocin were significantly decreased but were unchanged in lungs. 2. Prostaglandin inactivation was increased in kidneys of alloxan-diabetic rats but not changed in streptozotocin-diabetic kidneys or in the lungs of either group. 3. These chan...

To reveal the effects of Oldenlandia diffusa (OD) on relieving progression and development gestational diabetes mellitus (GDM), explore underlying mechanism. A rat model GDM was established by streptozotocin injection. The OD rats were evaluated measuring levels fasting blood glucose (FBG), insulin, hemoglobin A1c (HbA1c), exposing to oral tolerance test (OGTT) histological evaluation pancreas....

Aims: The present study aimed to evaluate anti-diabetic properties of AgNPs/chitosan/ascorbic acid nanocomposites (Ag-NCs) in streptozotocin-induced diabetic rats. Main methods: Eighteen male Wistar albino rats were divided into three main groups (6 rats/group); control, and Ag-NCs groups. Control group: after a single dose citrate buffer (0.1 mol/l, i.p), the orally received 1 ml distilled wat...

introduction: one of the main mechanisms by which diabetic complications occur is an alteration of the structure and function of proteins due to hyperglycemia. aspirin (asa) affects cellular pathways through different mechanisms, including glycation inhibition and antioxidant activity. the aim of the present study, as a follow up to our previous one, is to investigate the effect of long-term, h...

introduction: kisspeptin-13 (kp-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. however, the role of this peptide on cognition has not been well clarified yet. here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholin...

the present study was undertaken to determine whether two-month treatment of streptozotocin (stz)-diabetic rats with aqueous leaf extract of trigonella foenum-graecum (tfg 200 mg/kg i.p.) could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. for this purpose, vascular responses to kcl and noradrenaline (na) were measured. diabetic state significantly increased...