BACKGROUND Our understanding of the effect of ataxia-telangiectasia mutated gene mutations on brain structure and function is limited. In this study, white matter motor pathway integrity was investigated in ataxia telangiectasia patients using diffusion MRI and probabilistic tractography. METHODS Diffusion MRI were obtained from 12 patients (age range: 7-22 years, mean: 12 years) and 12 typic...

The transport and deposition properties of nanoparticles with a range of aerodynamic diameters ( 1 nm ≤ d ≤ 150 nm) were studied for the human airways. A finite element code was developed that solved both the Navier-Stokes and advection-diffusion equations monolithically. When modeling nanoparticle transport in the airways, the finite element method becomes unstable, and, in order resolve this ...

The white matter pathways of the brain can be reconstructed as 3D polylines, called streamlines, through the analysis of diffusion magnetic resonance imaging (dMRI) data. The whole set of streamlines is called tractogram and represents the structural connectome of the brain. In multiple applications, like group-analysis, segmentation, or atlasing, tractograms of different subjects need to be al...

Local maximum entropy (LME) meshfree basis functions are among the few approximants that possess Kronecker delta property on boundary, which enable to impose essential boundary conditions directly like FEM. This study presents potential of a method based LME approximation for Convection–Diffusion problem via well-celebrated SUPG. The present Streamline Upwind Petrov–Galerkin (SUPGM) benefits fr...

Diffusion magnetic resonance imaging (dMRI) and tractography provide means to study the anatomical structures within the white matter of the brain. When studying tractography data across subjects, it is usually necessary to align, i.e. to register, tractographies together. This registration step is most often performed by applying the transformation resulting from the registration of other volu...

Methanol limited fed-batch cultivation was applied for production of a plant derived beta-glucosidase by Pichia pastoris. The beta-glucosidase was recovered by expanded bed adsorption chromatography applied to the whole culture broth. The new Streamline Direct HST1 adsorbent was compared with Streamline SP. Higher bead density made it possible to operate at two times higher feedstock concentrat...

In this paper, we investigate adaptive streamline upwind/Petrov Galerkin (SUPG) methods for second order convection-diffusion-reaction equations with singular perturbation in a new dual norm presented [17] . The flux can be recovered two different manners: local averaging conforming H ( div ) spaces, and weighted global L 2 projection onto spaces. We further propose recovery stabilization proce...