Female pelvic floor dysfunction (FPFD) is a complex group of conditions that include urinary incontinence and pelvic organ prolapse (POP). In humans, elastin homeostasis has been implicated in the pathophysiology of FPFD. Lysyl oxidase-like 1 knockout (LOXL1-KO) mice demonstrate abnormal elastic fiber homeostasis and develop FPFD after parturition. We compared the lower urogenital tract (LUT) a...

BACKGROUND Lung cancer patients with chronic obstructive pulmonary disease (COPD) have a high risk of developing postoperative pneumonia (POP). This study aims to investigate the impact of COPD on POP and the trends for perioperative bronchial colonisation by micro-organisms. METHODS A retrospective chart review was made for 626 patients who underwent lung cancer surgeries at the Chiba Univer...

Current evidence suggests a multifactorial etiology to pelvic organ prolapse (POP), including genetic predisposition. We conducted a genome-wide association study of POP in African American (AA) and Hispanic (HP) women from the Women's Health Initiative Hormone Therapy study. Cases were defined as any POP (grades 1-3) or moderate/severe POP (grades 2-3), while controls had grade 0 POP. We perfo...

Microsatellites are multi-allelic and composed of short tandem repeats (STRs) with individual motifs composed of mononucleotides, dinucleotides or higher including hexamers. Next-generation sequencing approaches and other STR assays rely on a limited number of PCR amplicons, typically in the tens. Here, we demonstrate STR-Seq, a next-generation sequencing technology that analyses over 2,000 STR...

Two new species of the cyrtoscydmine ant-like stone beetle genus Syndicus are described: S. (s. str.) birmanicus sp. n. (from Myanmar) and S. (Semisyndicus) chiangmaianus sp. n. (from Thailand). A previously unknown male of S. (s. str.) puncticollis Jałoszyński is described, and for the first time the spermatheca of S. (Semisyndicus) sumatrensis Schaufuss is illustrated. Syndicus puncticollis, ...

With the continuous development of national economy, people's demand for spiritual culture is also increasing, and proportion tourism industry in increasing. Sports a new attractive way. The purpose this paper to analyze countermeasures sports resources (STR) by using analytic hierarchy process(AHP) promote tourism. This mainly uses AHP survey method carry out statistical analysis on relevant e...

Stromelysin-3 (STR-3) is a recently characterized matrix metalloproteinase i MMI'i that was cloned on the basis of differential expression in benign and malignant breast tumors. This M Ml' has a unique processing mechanism and substrate specificity. Unlike previously characterized MMi's that are secreted as inactive zymogens, STR-3 is processed within the constitutive secretory pathway and secr...

*) Institute for Medical Virology, Justus-Liebig-University, Frankfurter Str. 107, D-35392 Giessen, Germany †) Institute for Virology, Philipps University, Robert-Koch Str. 17, D-35037 Marburg, Germany #: present address: Paul-Ehrlich-Institute, Paul-Ehrlich Str. 51-59, D-63225 Langen, Germany ‡) Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Institute for Immunolog...

BACKGROUND Since 2004, treatment of Mycobacterium ulcerans disease, or Buruli ulcer, has shifted from surgery to daily treatment with streptomycin (STR) + rifampin (RIF) for 8 weeks. For shortening treatment duration, we tested the potential of daily rifapentine (RPT), a long-acting rifamycin derivative, as a substitute for RIF. METHODOLOGY/PRINCIPAL FINDINGS BALB/c mice were infected with M....

BACKGROUND Pelvic organ prolapse (POP) is a major health problem in adult women that involves many factors. No proteomic analysis has been conducted exclusively in POP patients. This study aimed to identify the differential expression of proteins that may be involved in POP by proteomic analysis. METHODS Samples of the uterosacral ligament (USL) were collected from five POP patients and five ...