Neurologic presentations in children with COVID-19 infection are rare. Reports of pediatric multi-inflammatory syndrome have dominated the literature, although cases pure neurologic manifestations been described.1–3 Akinetic mutism has previously reported steroid-responsive COVID-19-related encephalitis.4 We present case a 16-year-old girl who presented visual hallucinations and ritualistic beh...

The first known step in steroid hormone action is the association of the steroid with specific cytoplasmic steroid-binding proteins (SBP). Using a competitive binding assay, we detected, quantified, and partially characterized such a SBP in cytosol from glucocorticoid-sensitive human lymphoblastic leukemic blasts. The affinity of steroids for the SBP was directly related to their known killing ...

The aim of our study was to analyze endometrial gene expression profiles in ovariectomized cows treated with estradiol and/or progesterone by using microarray analysis. Clustering of differentially expressed genes allowed separation into distinct hormone response patterns. These patterns could be classified into independent and interdependent actions of the steroid hormones estrogen and progest...

The most common type of nephrotic syndrome in children is minimal change disease (MCD), which usually responsive to steroid therapy. Steroid dependency one the handicaps management these children. Thus, early prediction course may improve treatment strategy. Demographic characteristics and laboratory parameters 35 patients at time MCD diagnosis were retrospectively obtained from hospital record...

Cyclin D1 is a cell cycle control protein that plays an important role in regenerating liver and many types of cancer. Previous reports have shown that cyclin D1 can directly enhance estrogen receptor activity and inhibit androgen receptor activity in a ligand-independent manner and thus may play an important role in hormone-responsive malignancies. In this study, we examine a distinct mechanis...

AIMS To determine the benefits and toxicity of different corticosteroid regimes in preventing relapse in steroid responsive nephrotic syndrome. DESIGN Meta-analysis of randomised controlled trials. SUBJECTS Twelve trials involving 868 children aged 3 months to 18 years. MAIN OUTCOME MEASURE Frequency of relapse. RESULTS A meta-analysis of five trials, which compared two months of predni...

The steroid hormone androstenedione profoundly influences the development and expression of sexual and aggressive behavior. The neural basis of these effects are, however, poorly understood. In this study we evaluated androstenedione's ability to maintain vasopressin peptide levels in the gonadal steroid-responsive vasopressin cells of the bed nucleus of the stria terminalis and the centromedia...