The 20 standard amino acids together with 64 tri-nucleotide codons selected in the genetic code constitute a paradigm of complexity in Nature. Atomic rationals for the choice of nucleobases by Nature have recently received much attention. For the importance of stereoelectronic effect in noncovalent intermolecular interaction and biomolecular recognition, the nitrogen atoms of sp hybrid in nucle...

The 1.8 A resolution structure of the glycosyl-enzyme intermediate formed on the retaining beta-1,4-xylanase from Bacillus circulans has been determined using X-ray crystallographic techniques. The 2-fluoro-xylose residue bound in the -1 subsite adopts a 2,5B (boat) conformation, allowing atoms C5, O5, C1, and C2 of the sugar to achieve coplanarity as required at the oxocarbenium ion-like trans...

In this report we describe the synthesis of oligonucleotides containing sulfide-linked dinucleoside units, namely rT(2'OH)sdT, rT(2'OMe)sdT, dTsrU(2'OMe) and dT(2'OMe)srU(2'OMe). We also describe the interactions of such oligomers with complementary DNA and RNA targets, and provide the structural basis for their remarkable RNA binding selectivity. In all cases, the Tm values of the S/P-chimera ...

A regioselective fluorocyclisation of β,γ-unsaturated oximes through I(I)/I(III) catalysis is disclosed to generate 5-fluoromethylated isoxazolines. The transformation leverages p-iodotoluene as an inexpensive catalyst, Selectfluor® the terminal oxidant and amine⋅HF complex (1 : 7.5) both fluoride Brønsted acid source. λ3-iodane p-TolIF2, which generated in situ, engages pendant alkene substrat...