Dolutegravir, cabotegravir, and bictegravir are three integrase inhibitors, which were used for HIV-1 in the clinic. In this paper, a continuous three-step synthetic strategy was developed to prepare dolutegravir, better yield, compared initial step-by-step procedure. Different solvents, temperature, times optimized. course of industrial production active pharmaceutical ingredient (API), protoc...

Traj ectory modification of recurrent neur al networks is a training algorithm that modifies both th e network representat ions in each tim e step and th e common weight matrix. The present algorithm is a genera lization of th e energy minimization formalism for tr ainin g feed-forward networks via modifications of th e int ern al represent ati ons. In a previous paper we showed that th e same ...

The Intelligent Virtual Station (IVS) has been developed by the Smart Systems Research Laboratory at the NASA Ames Research Center as a solution to some of the training and operations challenges faced by organizations like the International Space Station training facilities and Mission Control engineering teams. At present, astronaut crews are constrained by limited access to physical mockups, ...

Procedural competency is a substantial part of the emergency physician’s (EP) skill set. Emergency Medicine (EM) is unique in that the practicing EP must be comfortable with a wide array of procedures that have the following features: 1) They span the entire human body and cross many disciplines in medicine and surgery; 2) There are both invasive and non-invasive procedures; 3) They occur at un...

We examine the formation of giant elliptical galaxies using their globular cluster (GC) systems as probes of their evolutionary history. The bimodal distributions of GC metallicities in such galaxies are often cited as evidence for the formation of giant elliptical galaxies through mergers involving gas-rich spirals, with the metal-rich GCs forming during the merger process. We explore an alter...