نتایج جستجو برای: stemness feature
تعداد نتایج: 237628 فیلتر نتایج به سال:
Human embryonic stem cells (hESCs) have been reported to exert cytoprotective activity in the area of tissue injury. However, hypoxia/oxidative stress prevailing in the area of injury could activate p53, leading to death and differentiation of hESCs. Here we report that when exposed to hypoxia/oxidative stress, a small fraction of hESCs, namely the SSEA3+/ABCG2+ fraction undergoes a transient s...
objective: ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (mdma), is a potent neurotoxic drug. one of the mechanisms for its toxicity is the secondary release of glutamate. mouse embryonic stem cells (mescs) express only one glutamate receptor, the metabotropic glutamate receptor 5 (mglu5), which is involved in the maintenance and self-renewal of mescs. this study aims to investigate whethe...
Loss or dysfunction of tumor suppressor retinoblastoma (RB) is a common feature in various tumors, and contributes to cancer cell stemness and drug resistance to cancer therapy. However, the strategy to suppress or eliminate Rb-deficient tumor cells remains unclear. In the present study, we accidentally found that reduction of DNA replication licensing factor MCM7 induced more apoptosis in RB-d...
“any science seeks generalities; the aim is to transcend knowledge of particular cases by discovering general regularities or laws” (chesterman, 2001, p. 1). these were the words of chesterman whose paper has served as a typical example of numerous papers carried out on ‘translation universals’ since the mid-nineties. blum-kulka (1986) is among translation studies scholars who proposed ‘explici...
Stemness Revisited: A Meta Analysis of Stem Cell Signatures Using High-Throughput Data Integration
We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, which overcomes the earlier achievements. We propose a constructive and transpare...
Abstract Background Additional epidermal growth factor receptor (EGFR) mutations confer the drug resistance to generations of EGFR targeted tyrosine kinase inhibitor (EGFR-TKI), posing a major challenge developing effective treatment lung adenocarcinoma (LUAD). The strategy combining EGFR-TKI with other synergistic or sensitizing therapeutic agents are considered promising approach in era preci...
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