Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful mathematical model for drug release from a drug delivery device and consecutive drug transport in biological tissue, thereby aiding the development of new therapeuti...

The static softening behavior of A5083 aluminum alloy with different initial microstructures was studied using various characterization techniques. To calculate the recrystallized fraction, in compression test, a new method based on offset yield stress and Hall–Petch relationship proposed, which is more accurate than conventional methods applicable even when microstructure complex. And relaxati...

Experimental data on the kinetics of propane hydrate dissociation at 0.1 MPa and different external temperatures were obtained. A two-stage mechanism of hydrate dissociation was observed visually. In the first stage hydrate dissociated into metastable water and gas. During the second stage the metastable water crystallized into ice. The release of metastable water during hydrate dissociation an...

The static softening behavior of A5083 aluminum alloy was studied through two thermomechanical tests, namely double-pass compression test and stress relaxation test. Metadynamic recrystallization the further conventional cannot achieve complete recrystallization, which means that in test, traditional method used to determine recrystallized fraction is no longer applicable. Hence, a new proposed...

Strip casting is an emerging technology for flat products; it is based on the concept of near-net shape casting; it holds potential for substantial energy saving and reduction in environmentally undesirable emission. In conventional thermo-mechanical processing, the pinning pressure due to the effects of Nb and NbC on boundary mobility is used to advantage to retard static recrystallisation and...

A kinetic model for the diffusion-controlled annealing of excess vacancies under the experimentally relevant, non-isothermal condition of time-linear heating is presented and applied to dilatometry. The evolution of the vacancy concentration with time is quantitatively analyzed, considering as ideal sinks either dislocations or grain boundaries of spherical- or cylindrical-shaped crystallites. ...