background: mechanotransduction plays a pivotal role in remodeling and repair of skeletal tissues. this mechanism has been widely used in bone tissue engineering especially under in vitro conditions. to date, various stem cells have been used for this purpose. the present study was thefirst to evaluate the effect of mechanical loading on differentiation of human endometrial stemcells (hescs) to...

Betacellulin (BTC) is a peptide ligand that belongs to the epidermal growth factor family, members of which are implicated in skin morphogenesis, homeostasis, repair, and angiogenesis; however, role BTC regulation barrier remains unknown so far. To examine function, we analysed data from two independent Gene Expression Omnibus (GEO) datasets evaluated effects on primary human keratinocytes usin...

The epithelium of upper respiratory tissues such as human nasal mucosa forms a continuous barrier via tight junctions, which is in part thought to be regulated through a protein kinase C (PKC) signaling pathway. To investigate the mechanisms of the regulation of PKC-mediated tight junction barrier function of human nasal epithelium in detail, primary human nasal epithelial cells were treated wi...

open-channel junctions have a broad application in civil and environmental engineering. formation of a low-pressure zone with recirculating flow (high sedimentation) accompanied by a high-velocity zone (high erosion) is the most characteristic feature of flow in junctions. a large number of researches have been performed to study the complexity of the flow in junctions in open-channel flows. in...

Background: Congenital hearing loss due to different genetic and environmental causes affects 1 in 1000 newborns. Mutations in the GJB2 (Gap Junction Beta-2) gene encoding the gap junction protein connexin 26 have been established as the main cause of autosomal recessive non-syndromic hearing loss. Materials and methods: The aim of this study was to study the frequency of GJB2 Mutations in Lor...

Background: Hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. We previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) modulates epileptogenesis in rats. There is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. Gap junction channels are formed ...

Formation of pseudoislets from rodent cell lines has provided a particularly useful model to study homotypic islet cell interactions and insulin secretion. This study aimed to extend this research to generate and characterize, for the first time, functional human pseudoislets comprising the recently described electrofusion-derived insulin-secreting 1.1B4 human β-cell line. Structural pseudoisle...

1 gastrocnemius muscle-tendon unit in vivo. Abstract 9 Static stretch is commonly used to prevent contracture and to improve joint mobility. 10 However, it is unclear whether the components of the muscle-tendon unit are affected 11 by a static stretch training program. This study investigated the effect of a four-week 12 static stretch training program on the viscoelastic properties of the musc...

background: hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. we previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (lps) modulates epileptogenesis in rats. there is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. gap junction channels are formed ...