BACKGROUND Recently, the accuracies of many commercially available immunoassays for Vitamin D have been questioned. Liquid chromatography tandem mass spectrometry (LC- MS/MS) has been shown to facilitate accurate separation and quantification of the major circulating metabolite 25-hydroxyvitamin-D3 (25OHD3) and 25-hydroxyvitamin-D2 (25OHD2) collectively termed as 25OHD. However, among other int...

Airway mucus hypersecretion is a significant clinical and pathological feature of chronic inflammatory airway diseases. Its clinical presentations include recurrent coughing and phlegm. Airway mucus is closely associated with the occurrence, development and prognosis of chronic inflammatory airway diseases and critically affects the lung function, quality of life, hospitalization rate and morta...

Current data suggest that the use of anabolic androgenic steroids (AAS) has become quite common among athletes, bodybuilders, as well as adolescents and young adults who want to increase their muscle mass for aesthetic or athletic reasons. Commonly used anabolic steroids are the oral 17a alkyl derivatives of testosterone (methyl testosterone, oxymetholone, oxandrolone, stanozolol) and the intra...

Anabolic steroids (ABS) boldenone (BL; 1.1 mg/kg) and stanozolol (ST; 0.55 mg/kg) were administered i.m. to horses and the plasma samples collected up to 64 days. Anabolic steroids and androgenic steroids (ANS) in plasma were quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The limit of detection of all analytes was 25 pg/mL. The median absorption (t1/2 partial differ...

Abstract Background The pervasiveness of doping and findings anti-doping corruption threaten weightlifting’s position at the 2024 Olympic Games. Analysing practices in weightlifters could identify patterns that assist future detection. Methods We analysed publicly available data on sanctioned athletes/support personnel from International Weightlifting Federation between 2008 2019 announced retr...

Hereditary angioedema (HAE) due to C1-inhibitor de ciency is a rare autosomal dominant disease characterized by recurrent episodes of transient localized swelling of the subcutaneous and/or mucosal tissues that can occur anywhere in the body. Acute abdominal pain due to mucosal swelling of the gut is one of the most common presentations of HAE, leading frequently to unnecessary abdominal surger...