We report the nucleotide and predicted amino acid sequence of the matrix (M) gene of the Halle" strain of measles virus cloned from a pcD library (1). The analysis shows that the sequence is highly conserved compared with the prototype Edmonston sequence (2), containing only three amino acid changes (underlined). In contrast, other SSPE strains have been shown to contain high nucleotide mutatio...

The paramyxoviruses measles (subacute sclerosing panencephalitis, SSPE) virus and canine distemper virus (CDV) cause an impairment of the catecholamine-induced beta-adrenergic receptor-dependent cAMP generation in persistently infected C6 rat glioma cells. In C6 cells persistently infected with CDV the number of receptors is greatly reduced. Hirata and Axelrod have shown that the number of beta...

Encephalitis is an inflammation of the brain. The diagnosis of encephalitis can be established only by microscopic examination of brain tissue, and similarly the etiology is established only by the recovery from or the demonstration in brain tissue of an infectious agent. In clinical practice, however, the diagnosis of encephalitis frequently is based on neurologic manifestations, and the etiol...

The nucleotide sequence has been determined for the matrix (M) protein gene of three strains, Niigata-1, ZH and Biken, of cell-associated subacute sclerosing panencephalitis (SSPE) virus. The M proteins of the Niigata-1 and ZH strains were found to terminate prematurely as a result of nonsense mutations at nucleotide positions 68 and 96 respectively. On the other hand it was predicted that the ...