This paper explores social scientists' and humanities (SSH) scholars' integration within the academic medical research environment. Three questions guided our investigation: Do SSH scholars adapt to the medical research environment? How do they navigate their career within a culture that may be inconsistent with their own? What strategies do they use to gain legitimacy? The study builds on thre...

PURPOSE Uveal melanoma (UM) is the most common primary cancer of the eye, resulting not only in vision loss, but also in metastatic death. This study attempts to identify changes in the patterns of gene expression that lead to malignant transformation and proliferation of normal uveal melanocytes (UVM) using the Suppressive Subtractive Hybridization (SSH) technique. METHODS The SSH technique ...

Introduction Conclusions References Tables Figures Back Close Full Screen / Esc Abstract Introduction Conclusions References Tables Figures Back Close Full Screen / Esc Abstract On the basis of model simulations, we examine what information on changes in the strength of the Atlantic Meridional Overturning Circulation (AMOC) can be extracted from associated changes in sea surface height (SSH), s...

Comparative bacterial genomics shows that even different isolates of the same bacterial species can vary significantly in gene content. An effective means to survey differences across whole genomes would be highly advantageous for understanding this variation. Here we show that suppression subtractive hybridization (SSH) provides high, representative coverage of regions that differ between simi...

This paper presents a novel technique for obtaining implementations of security protocols, proved secure in the computational model. We formally specify the protocol to prove, we prove this specification using the computationally-sound protocol verifier CryptoVerif, and we automatically translate it into an implementation in OCaml using a new compiler that we have implemented. We applied this a...

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Suppression subtractive hybridization (SSH) is one of the most powerful and popular methods for isolating differentially expressed transcripts. However, SSH-generated libraries typically contain some background clones representing non-differentially expressed transcripts. To overcome this problem we developed a simple procedure that substantially decreases the number of background clones. This ...

Both the open source and the open access movements have their roots in the ‘hard’ sciences rather than in the social Sciences and Humanities (SSH). They have been concerned, traditionally, with open access to source code for computational data processing and with open access to scientific information published as journal articles. Still, the basic assumption of the present contribution is that ...

Thiamethoxam has been used as a major insecticide to control the B-biotype sweetpotato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae). Due to its excessive use, a high level of resistance to thiamethoxam has developed worldwide over the past several years. To better understand the molecular mechanisms underlying this resistance in B. tabaci, gene profiles between the thiamethoxam...

Salt-sensitive hypertension (SSH) is characterized by impaired sodium excretion and subnormal vasodilatory response to salt loading. Sacubitril/valsartan (LCZ696) was hypothesized to increase natriuresis and diuresis and result in superior blood pressure control compared with valsartan in Asian patients with SSH. In this randomized, double-blind, crossover study, 72 patients with SSH received s...