نتایج جستجو برای: sscs

تعداد نتایج: 935  

Mahdi Mohaqiq Manizheh Mokhtari Dizaji Mansoureh Movahedin Zohreh Mazaheri

Background  Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis. Sound wave especially low intensity ultrasound (LIUS) can be effective on increasing the number of cells. In this study we investigated the effect of LIUS stimulation on mouse SSCs proliferation and colonization. Methods: Isolated SSCs from neonate mice cultured in DMEM culture medium with 10% Fetal Bovine S...

Ghorbanian, Mohammad taghi, Mahal Dashtian, Maryam, Makoolati, Zohreh, Naghdi, Majid,

Spermatogenesis is a highly complex and regulated process in which germ stem cells differentiate into spermatozoa. These stem cells, called spermatogonial stem cells (SSCs), are in the base of seminiferous tubules and have the ability of self-renewal and differentiation into functional germ cells. Due to this ability, SSCs can restore spermatogenesis after testicular damage caused by cytotoxic ...

2017
Atsuki Fukutani Venus Joumaa Walter Herzog

Increased muscle force during stretch-shortening cycles (SSCs) has been widely examined. However, the mechanisms causing increased muscle force in SSCs remain unknown. The purpose of this study was to determine the influence of residual force enhancement and elongation of attached cross-bridges on the work enhancement in SSCs. For the Control condition, skinned rabbit soleus fibers were elongat...

2015
Narong TIPTANAVATTANA Araya RADTANAKATIKANON Poul HYTTEL Hanne HOLM Supranee BURANAPRADITKUN Piyathip SETTHAWONG Mongkol TECHAKUMPHU Theerawat THARASANIT

The development of germ cells has not been entirely documented in the cat especially the transition phase of the gonocyte to the spermatogonial stem cell (G/SSC). The aims of study were to examine testicular development and to identify the G/SSC transition in order to isolate and culture SSCs in vitro. Testes were divided into 3 groups according to donor age (I, < 4 months; II, 4-6 months; and ...

2012
Amber E. Kofman Margeaux R. McGraw Christopher J. Payne

Balancing quiescence with proliferation is of paramount importance for adult stem cells in order to avoid hyperproliferation and cell depletion. In some models, stem cell exhaustion may be reversed with the drug rapamycin, which was shown can suppress cellular senescencein vitro and extend lifespan in animals. We hypothesized that rapamycin increases the expression of oxidative stress response ...

Journal: :Journal of Biomedicine and Biotechnology 2001
Joshua R Merok James L Sherley

Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs retain these growth kinetics in vitro, a natural kinetic barrier to SSC propagation exists. Recen...

1999

A significance determination process (SDP) is proposed that assigns risk characterization to inspection findings based on large early release frequency (LERF) considerations. This process is designed to interface directly with the SDP that is based on findings related to those structures, systems, and components (SSCs) that can influence the core damage frequency (CDF). The proposed LERF-based ...

2014
Tao Tan Yanfeng Zhang Weizhi Ji Ping Zheng

Spermatogonial stem cells (SSCs) play fundamental roles in spermatogenesis. Although a handful of genes have been discovered as key regulators of SSC self-renewal and differentiation, the regulatory network responsible for SSC function remains unclear. In particular, small RNA signatures during mouse spermatogenesis are not yet systematically investigated. Here, using next generation sequencing...

2016
Na Cui Guimin Hao Zhiming Zhao Feng Wang Jinfeng Cao Aimin Yang

MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems, where their functions include the regulation of self-renewal, cellular differentiation, proliferation and apoptosis. However, the function and mechanisms of individual miRs in regulating spermatogonial stem cell (SSC) homeostasis remain unclear. In the present study, we report for the first tim...

2015
Yuri Miura Noritaka Hashii Hiroki Tsumoto Daisuke Takakura Yuki Ohta Yukiko Abe Yasumichi Arai Nana Kawasaki Nobuyoshi Hirose Tamao Endo Jon M. Jacobs

An N-glycomic analysis of plasma proteins was performed in Japanese semisupercentenarians (SSCs) (mean 106.7 years), aged controls (mean 71.6 years), and young controls (mean 30.2 years) by liquid chromatography/mass spectrometry (LC/MS) using a graphitized carbon column. Characteristic N-glycans in SSCs were discriminated using a multivariate analysis; orthogonal projections to latent structur...

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